The oxidative state of chylomicron remnants influences their modulation of human monocyte activation.

Lipid Accumulation in Primary Human Monocytes after Incubation with CRLP, pCRLP, or oxCRLP After 24 h incubation, Oil Red O staining for lipid was increased in monocytes coincubated with CRLPs or oxCRLPs, at a concentration of 15 μ g/mL cholesterol ( Figure 1(a) ), and quantitative analysis of the staining density showed that the changes were highly significant in comparison to control cells ( Figure 1(b) ).

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This is likely to be significant for development of atherosclerosis, taken together with the finding that removal of CMR from the blood is delayed in several common conditions such as obesity and type 2 diabetes [ 34 ].

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Uptake also appeared to be increased after incubation with the higher concentration of CRLP or oxCRLP (30 μ g cholesterol/mL); however, in this case the changes did not reach statistical significance.

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