IPGTT testing of mice heterozygous for a null mutation of Sox4 has been reported to have nonsignificant differences in glucose tolerance at the 30-min time point of the test; however, there was a clear trend of increased blood glucose concentrations in heterozygotes at all of the IPGTT time points after fasting shown ( 23 ).
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Role of the transcription factor sox4 in insulin secretion and impaired glucose tolerance.
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