Intraperitoneal G-CSF Stimulation Achieves Human-like Neutrophil Levels in NSG Mice Without Inducing Systemic Inflammation.

Although NE activity was numerically higher in all treated groups compared to the controls, these differences did not reach statistical significance ( Figure 4 A).

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Three key findings emerged (I) repeated G-CSF dosing induced a substantially stronger and more consistent neutrophil response in the peripheral blood, bone marrow than single-dose regimens, with a numerical trend towards increased neutrophil abundance also observed in the spleen, (II) single-dose administration resulted in only minor or non-significant effects regardless of the dose; and (III) neutrophil expansion occurred without evidence of systemic inflammation, as indicated by stable plasma NE activity and cfDNA levels across all groups. 3.2.

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