The Immunomodulatory Role of Gemcitabine in Triple Negative Breast Cancer.

While changes in immune populations were observed in each individual experiment, variation within groups (which is expected in such studies) meant some of these findings failed to reach significance.

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While individual experiments did not reach statistical significance, after combining data, there was a small but significant increase in pan-MDSCs (GR1 + ) (1.1 FC, p = 0.0006) and granulocytic MDSCs (Ly6G + ) (1.1 FC, p = 0.0089) in the tumour, as well as a decrease in granulocytic MDSCs (0.7 FC, p = 0.0061) in the spleen ( Figure S4 ).

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While there were no significant changes, there was a small trend in decreasing tumour T-helper cells after GEM treatment.

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