Age-related Eye Disease Studies Supplements and Genetic Risk Score Are Crucial Determinants of Intestinal Microbial Alterations in Advanced Age-Related Macular Degeneration.

Ophthalmol Sci · 2026 · PMC12547908 · PMID 41140896

Europe PMC DOI

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closest p · 1.2× alpha

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showed a trendP = 0.06so close (0.05 < p ≤ 0.1)

Bacterial flow cytometry analysis of AMD fecal samples ( Fig 4 A) showed a trend toward increased IgA-coated bacteria with higher AMD GRS ( P = 0.06; Spearman’s r = 0.2) ( Fig 4 B).

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a trend toward significanceP = 0.06so close (0.05 < p ≤ 0.1)

To complement the supervised data, we also utilized an unsupervised method called PCoA, which also showed dissimilarity between AMD and control subjects, with a trend toward significance by PERMANOVA analysis ( P = 0.06) after adjusting for age ( Fig 3 B).

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