The safety and efficacy of long-term use of calcitonin analogs in the treatment of osteoporosis in the elderly: a pharmacovigilance and RCT meta-analysis.

Front Pharmacol · 2025 · PMC12515915 · PMID 41089842

Europe PMC DOI

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closest p · 0.8× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.04actually significant

an increasing trendno p-value reported

Three studies assessed changes in femoral neck BMD, and the random-effects model showed an increasing trend (SMD = 0.24, 95% CI: −0.01–0.49), but this did not reach statistical significance, with moderate heterogeneity (I 2 = 70%, p = 0.04).

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a decreasing trendno p-value reported

(2012) reported a decreasing trend in NTx-1 levels (SMD = −0.13, 95% CI: -0.37 to 0.11), while Iwamoto et al.

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