Sex-specific predictive value of reticulated platelets in coronary artery disease: A systematic review and meta-analysis.

Although these results are influenced by the limited number of included studies—which may explain why the increased risk in males did not reach statistical significance—the higher rate of cardiovascular death observed in females appears robust enough to overcome their underrepresentation.

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For cardiovascular death RPs were predictive in females (OR 3.29 [95% CI 1.69, 6.40] I 2 = .83%) and showed a trend toward significance in males (OR 2.19 95% CI [.98, 4.9] I 2 = 42.72%).

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This patient‐level sex subanalysis further highlights a stronger association between RPs high and CVD in females (229% increased risk) compared to males (119% increased risk), although the latter narrowly missed statistical significance.

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