Richter transformation in diffuse large B-cell lymphoma in patients with chronic lymphocytic leukemia receiving ibrutinib: risk factors and outcomes.

Leukemia · 2025 · PMC12310524 · PMID 40562789

Europe PMC DOI

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0.0710

closest p · 1.4× alpha

0.0710

boldest claim

The sentences

a trend towards significancep = 0.071so close (0.05 < p ≤ 0.1)

When we analyzed risk factors of developing RT in the cohort of 269 patients treated front-line, in multivariable analysis, Rai stage I-II showed independent significance (HR, 12.73 [95% CI: 1.6498.72]; p = 0.015) with a trend towards significance for TP 53 deletion/mutation (HR, 4.07 [95% CI: 0.89–18.63]; p = 0.071) (Table 3 ).

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