Allelic expression patterns of imprinted and non-imprinted genes in cancer cell lines from multiple histologies.

The difference between imprinted and other monoallelically expressed genes was highly significant ( p < 10 –15 ), which is consistent with the imprinting mechanism, when an allele is expressed or silenced due to its parental origin without regard to the presence of a specific base.

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In our previous study of gene-level expression [ 63 ], many of them were weakly associated with drug response but did not reach statistical significance (data not shown), suggesting an improved resolution when using isoform level data.

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