Barely Significant
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Longitudinal associations between pain and cognitive decline in middle-aged and older Chinese adults: the mediating role of depressive symptoms.

Front Public Health · 2025 · PMC11994437 · PMID 40231182

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a negative trendno p-value reported
Conversely, the cohort experiencing rapid cognitive decline demonstrated a consistent deterioration in both memory and affective state, indicating a potential lack of effective cognitive preservation strategies and a negative trend in cognitive performance within this demographic ( 56 ).

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