Altered Reward Circuit Function Moderates the Relationship between Childhood Maltreatment and Depression Severity in Adolescents.

Depress Anxiety · 2023 · PMC11921849 · PMID 40224590

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did not reach statistical significanceno p-value reported

However, the interaction between RSFC of DMPFC-pGP and childhood neglect in model 3 did not reach statistical significance.

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close-to-significantno p-value reported

Our analysis revealed a close-to-significant association with anhedonia severity, with an r -value of 0.199 and a p value of 0.086.

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failed to attain significanceno p-value reported

To further decompose the interaction effects of RSFC between the DMPFC and the pGP, as well as traumatic experiences (given that model 3 failed to attain significance, only the CTQ total score and childhood abuse were incorporated) on the severity of AO-MDD, patients with AO-MDD were stratified into high, medium, and low reward circuit function groups.

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