Coenzyme Q10 mitigates macrophage mediated inflammation in heart following myocardial infarction via the NLRP3/IL1β pathway.

Compared with MI mice treated with vehicle, the survival rate of MI mice treated with CoQ10 showed an increasing trend throughout the time course (61.90% vs. 42.85%, log-rank test p = 0.286; Fig. 2 A).

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In animal models, we used LAD ligation to establish an experimental MI model, and we found that in the absence of baseline CoQ10 deficiency and the use of statins that affect CoQ10 levels, the single use of CoQ10 treatment showed a trend of improved survival rate, significantly reduced BNP levels, improved cardiac dysfunction, and adverse cardiac remodeling induced by MI, further supporting that early supplementation with CoQ10 is beneficial for improving MI prognosis.

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In mice study, compared to vehicle-treated MI mice, CoQ10-treated MI mice showed a favorable trend in survival rate (42.85% vs. 61.90%), as well as significantly alleviated cardiac dysfunction, myocardial fibrosis, and cardiac hypertrophy.

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