The Pathophysiology of Gilles de la Tourette Syndrome: Changes in Saccade Performance by Low-Dose L-Dopa and Dopamine Receptor Blockers.

At the end of the follow-up period, the motor tic was significantly lower in the L-Dopa group than in the no L-Dopa group, whereas the vocal tic showed a trend to be slightly but not significantly lower in the L-Dopa group.

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Impaired Inhibitory Control of Saccades in GTS GTS patients with prior blocker use showed an increased frequency of saccades to the cue compared with normal participants, although the difference in the frequency just failed to reach significance when drug-naïve GTS patients were compared with normal participants ( Figure 6 B).

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They showed a decreasing trend and a failing significance for the vocal tic and a non-significant change for the OCD subscores (motor: F 1,10 = 17.500, p = 0.0019, vocal: F 1,10 = 4.865, p = 0.0519, OCD: F 1,10 = 0.129, p = 0.7287 for the respective subscores).

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