Baseline tumor gene expression signatures correlate with chemoimmunotherapy treatment responsiveness in canine B cell lymphoma.

PLoS One · 2023 · PMC10456153 · PMID 37624862

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nearing significanceno p-value reported

For dogs who received RV1001, AKT3 and PIK3CD were confirmed to be overexpressed in good responders via qPCR (with significance for PIK3CD and nearing significance for AKT3 ).

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approaching significanceno p-value reported

PIK3CD is the gene that encodes for the primary target of RV1001 (PI3Kδ) and was increased in good responders at baseline with approaching significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.