Fractionated Stereotactic Radiotherapy with Helical Tomotherapy for Brain Metastases: A Mono-Institutional Experience.

J Pers Med · 2023 · PMC10381210 · PMID 37511711

Europe PMC DOI

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0.1100

closest p · 2.2× alpha

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The sentences

did not reach statistical significancep = 0.11not close (p > 0.1)

In agreement with the abovementioned studies, in our series, better LC rates were also found to be predictive of improved intracranial progression-free survival, although this did not reach statistical significance ( p = 0.11); nonetheless, this evidence supports the role of local treatments as an alternative strategy to delaying the administration of salvage whole brain radiotherapy or the initiation of new systemic agents.

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a favorable trendp = 0.11not close (p > 0.1)

The UA showed better IPFS rates significantly related to male sex ( p = 0.049), a BED 12 of ≥42 Gy ( p = 0.006), and controlled extracranial disease ( p = 0.03); in the MA, a favorable trend towards LC ( p = 0.11) and higher BED ( p = 0.11) schedules maintained a correlation with improved IPFS rates, although statistical significance was not reached.

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