Epigallocatechin-3-Gallate Alleviates Liver Oxidative Damage Caused by Iron Overload in Mice through Inhibiting Ferroptosis.

No significant trend of elevated mRNA and protein expression of TFR1 was induced by excessive iron intake, but it was significantly decreased by the addition of EGCG, while it caused a highly significant increase in TFR1 gene and protein expression in the control group ( Figure 7 c,f,h) ( p < 0.01).

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Surprisingly, the effects of excessive iron intake on serum and liver GSH or GSSG did not reach statistical significance ( Figure 5 e,f,h), while high iron significantly decreased the GSH/GSSG ratio ( Figure 5 g) ( p < 0.01), which also indicated that lipid peroxidation occurred in the mouse liver.

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