Intact Proviral DNA Analysis of the Brain Viral Reservoir and Relationship to Neuroinflammation in People with HIV on Suppressive Antiretroviral Therapy.

Intact proviruses showed a trend toward higher levels in the CD4 count ≥350 vs. <350 group (median 35 vs. 3 copies/10 6 cells, respectively, p = 0.06), while total proviruses were similar (median 1102 vs. 1047 copies/10 6 cells, respectively, p = 0.7) ( Figure 1 ).

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In contrast, there was an increasing trend in intact proviruses in brains with vs. without neuroinflammatory pathology (56 vs. 5 copies/10 6 cells, p = 0.1), but no significant differences in defective or total proviruses.

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