“very close to significance”

We detected two significant SNPs on chromosomes 3 and 12 for lupanine, three significant SNPs on chromosomes 3, 7, and 21 (the latter with a very high association score) for 13α-hydroxylupanine, and two significant SNPs on chromosomes 9 and 21 plus one very close to significance on chromosome 11 for 13α-angeloyloxylupanine (Fig. 4 ).

In the analysis of their individual associations with antibody levels, 2 of the biomarkers (CD6 and HGF) showed a significant negative association, and the biomarker MCP-2 obtained a positive association very close to significance ( Table 5 ).

We found a greater number of oncological causes compared with the Italian population, and this number was very close to significance, while stroke and cardiovascular death showed a similar HR as the general population.

All tests were significant at the Bonferroni corrected threshold α = 0.008, except for the number of non-zero voxels between the Action maps, which was still very close to significance, and the mean of non-zero voxels of the Interoception domain, which was non-significant.

Again, this was also reflected in the questionnaires where no participant in the EG agreed with the statement “Cannot play while watching the feedback.” Besides, the EG's also seemed to improve more in that descriptor in the rest of the conditions to the point of giving results very close to significance in the Transfer condition.

The trend was significant for the SoC group and was very close to significance in the IVIG group.

Cumulative probability of having this ratio (eight or more out of 10) by chance was calculated to be p = 0.0547, which is very close to significance at α = 0.05.

In the pharmacological experiment, expression of hippocampal Acet/Total-Tub was still increased in Fmr1 -KO mice with a trend very close to significance when compared to WT counterparts, while Tyr/Glu-Tub was not found decreased as it was observed in the first cohort of untreated animals.