“quite significant”

12 The results showing the improved activity of ASO in some patient-derived CTCs via GalNAc conjugation are quite significant, in that they demonstrated a potential use of CTCs to select a subgroup of HCC patients whose tumors express functionally active ASGR and, thus, are likely to be sensitive to GalNAc-conjugated ASOs.

When combined with transport, or reimbursed fares (discussed next), the medical benefits were therefore felt to be quite significant especially for the scenarios 3, 4 and 5.

For this case, the difference of the maximum value and the standard deviation between the left and right sides is quite significant.

In most of the cases this decrease was quite significant (miR164, miR165/166, miR169 and miR170).

Furthermore, the correlations between each pair among the annual precipitation, annual precipitation in the wet season, annual precipitation in the dry season, and annual torrential rain days are quite significant.

The developed conclusions draw attention to a quite significant social problem and the far-reaching effects of the use of violence against children and the need to take preventive and therapeutic measures, including the protection of children’s rights.

But it is also quite significant to develop symmetric devices because it can also reduce the dependence on carbon materials.

It is possible that the cumulative effect of these exposures is quite significant or relatively limited, but more detailed research would help the malaria control community determine the value of targeting malaria prevention resources towards protecting those who sleep away from home for different reasons.

These trends are quite significant and are relatively easy to observe in alpine regions by comparisons with historic photographs.

As the United Nations (UN) Human Rights Council working group on the issue of discrimination against women in law and practise ( 54 ) emphasises, the problem of clandestine abortions is quite significant because “unsafe abortions cause the deaths of some 47,000 women each year and a further five million suffer some form of temporary or permanent disability.” From a psychological point of view, because the nature of unwanted pregnancy and subsequent abortion causes women to perceive a lack of freedom regarding the control of their lives or bodies, women often feel compelled to keep their choice a secret, or they feel delegitimized in their suffering ( 55 ).

Of the 14 miRNAs, 6 were predicted from EST sequences (2.96% per 10,000 ESTs) and 8 were identified from GSSs (7.45% per 10,000 GSSs).These values are quite significant as compared to miRNA candidates from other plant species [ 5 ] and confirmed that EST and GSS analysis could be efficiently used to predict miRNAs in plants.

Although apparently minor, small changes in nucleosome spacing are likely to have profound changes in the local chromatin structure 41 and given the role of CTCF in determination of the topological associated domain (TAD) structures, this may lead to quite significant changes of high‐level chromatin architecture and hence gene regulation.

The finding that early antidepressant use is associated with higher negative affect and impulsivity, even years later during a period of euthymia, is quite significant!

As in our study, the psychological and social effects of electrical burns are quite significant.

The interaction between cyanidin-3-O-rutinoside and FABP4 (a fatty acid-binding protein) was quite significant, exhibiting a binding affinity of −10.4 kcal/mol.

It is observed that interaction between the height of drop and occupant posture angle is quite significant. 4.

Comparison of optimal Net Present Values (NPVs) can also provide valuable insight and alternative process designs for different APIs, but are subject to API sales price variation, which may be quite significant for certain drugs (e.g., artemisinin).

The incidence of this condition is low, but its association with pregnancy is quite significant.

The greater intensity of these relationships appeared to be associated with quite significant emotional strain, on top of the work of grief.

“Increased utilization” may have been the wrong wording, rather “successful application”; the discussion sentence was changed to: “In summary, the effect of PGx reports newly made available to medical staff in this context seems quite significant as observed by the individual PGx dosing/metabolizer status, DGI and DDI recommendations showing a corresponding modification of the medication regimen for each patient.

This is quite significant as with each change of therapeutic class, the likelihood of attaining a clinical response to subsequent therapy reduces by 27% in previously TNFi-experienced patients. 14 Our data shows that combining UST and VDZ can help overcome the phenomenon of sub-optimal remission and response rates in TNFi experienced patients.

A modest decrease under UV and quite significant decrease under visible light for phenol photo-degradation can be seen in Figure 9 .

Things like that to try and arrange it so that you’re getting the best conditions.” (P11) Clinicians described taking a person-centred approach to understand the clients’ needs and adapt sessions to ensure there is no impact on their experience or validity of testing: “I had one lady I worked with who had quite significant respiratory issues.

The alpha value (ratio between the variance of the inefficiency model and the total variance) is 0.564; following [ 38 ], this means that about half of the random deviation in production from the frontier is due to technical (in)efficiency, so the inefficiency effects are quite significant in the analysis of the value of output of the farms.

Comparative analysis of these major bioactive compounds in different medical parts indicated that it was quite significant for in-depth exploitation of leaves and stems from American ginseng cultivated in the Heilongjiang districts of China.