“quite significant”

The resources required to obtain individual consent would be quite significant, including increased study personnel for recruitment and resulting costs.

Mass loss from the central remnant was often quite significant, with thick accretion disks or completely unbound material comprising up to 10–20% of the total system mass Mass loss was suppressed in numerical simulations by constructing irrotational, rather than synchronized, initial data.

Therefore, developing an effective strategy to reduce the reactivity of lattice oxygen is quite significant for improving the durability of catalysts, however, implementing this target remains a grand challenge.

The pattern of scoring showed that there was an increase in marks secured in both types of assessment which was quite significant.

All of the results were quite significant with the highest dose of F.A (400 mg/kg) and were comparable to furosemide.

Therefore, it is quite significant to obtain the conformational changes in GLP-2 under different electric fields using molecular dynamics simulations. 2.

The incidence of mitochondrial diseases due to a reduced capacity for complex I is now recognized to be quite significant.

This is quite significant, given the known variability associated with iPSC-derived cell models that can be confounded by donor variability and genetic stability of iPSCs among various factors ( 45 ).

Furthermore, the relatively novel and less explored class CI found improved alignments in a quite significant 26% of the instances in G1 and 34% of RV911 when compared with more traditional approaches.

pulex from different continents have quite significant differences in their DNA sequences and that mutation rates of the mitochondria genome are one of the highest among different species [ 41 ].

Note that sea level data may display quite significant trends (−1.7 cm/month in average), which leads to consider the data with caution for applications requiring a very stable vertical reference.

We conclude that the variation of the generation time due to reducing the contact activity of symptomatic individuals may be, as in this example, quite significant.

The morphological changes toward size reduction are quite significant.

Quite significant differences were also observed between the estimations of the causes of the patient’s fatigue made by the staff and the patient’s own estimations.

For use cases 2–4, we found quite significant differences between the workflow results; yielding different sets of pathways (use case 2), bias towards different PTM types (use case 3) and different quantification of low ratios (use case 4).

Since the ⟨τ⟩ change inflicted by TC10 and Cdc42 were quite significant, we next investigated their binding affinity for the open state mutant sensor and titrated F1 dmDA with increasing concentrations of TC10 and Cdc42.

Clinicians should carefully weigh risk versus benefit of factor concentrate administration as there is no evidence that these agents improve outcomes and the risk of thrombosis is quite significant [ 86 , 87 ].

We find that the discrepancies among different charge analysis schemes are quite significant, consistent with the observations reported by Choudhuri et al. 61 .

This is quite significant as our finding is in direct correlation with the crude-age-specific estimated suicide rates for Nigeria in the WHO Global Health Estimates. 2 Although our study did not evaluate suicidal plans and attempt, we believe our finding deserves more investigations as the WMHS also found that transition from suicidal ideation to first onset of plan or attempt is extremely elevated within the first one year of the ideation and decreases substantially thereafter.

In addition, the existing literature using both modeling and experiments has revealed that the effect of soil pH on NPP is quite significant [ 58 ], implying that soil properties are also major influencing factors on NPP.

These findings regarding attention and alertness are quite significant, especially if we contrast the relaxation response and clinical applications that seek to increase sleep duration/depth, with Buddhist texts and aims of enlightened awakening.

Compared to the Trp486 in chain C, the Trp486 of chain B flipped its indole ring, with quite significant conformational change of the surrounding residues (Supplementary Fig.

(i) Cl-atoms of the DCNO compound bear negligible negative charge, −0.004e, and thus would weakly participate in noncovalent intermolecular interactions. (ii) On the contrary, the oxygen atoms of the carboxyl and carbonyl groups of the DCNO anion moiety have quite significant negative charges, ca. −0.72 to −0.8e; therefore, they can participate effectively in both intramolecular and intermolecular H-bonding and electrostatic noncovalent interactions.

The standard deviation of the mean values of samples G1 and G2 is quite significant, a symptom of a certain inhomogeneity in the acquired results.

Nine factors were addressed and each one was rated by the respondents as extremely important, important, quite significant, some important, or not important at all.