Barely Significant
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“quite significant”

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Sighted at

p=0.0644p=0.07

Listed by Hankins, posted since · Hankins (2013) · Otte et al. (2022)

In the literature

quite significantqualifiedgold
16 The primary isotope effect is quite significant, reflecting that in the methane activating direction a thiyl radical abstracts a hydrogen atom from methane, which is a very endothermal reaction (Δ H o ≈ 70 kJ/mol) and which is not observed in nonenzymatic reactions because follow-up reactions of the thiyl radicals such as dimerization are much faster in solution.
quite significantqualifiedgold
During the catalytic cycle of HR-PKS, multiple stereogenic centers are introduced by the methyltransferase (MT), ketoreductase (KR), dehydratase (DH), and enoylreductase (ER) domains. While the unambiguous assignment of stereochemistry is time-consuming, it is quite significant in developing natural product-based pharmaceuticals.
quite significantqualifiedgold
3 D, it is obvious that, when PBS or NR-CLB (the control chromophore without azo linkage) was injected intratumorally, no fluorescence could be observed; while after NR-azo injection, the fluorescence signal in the tumor region was quite significant, indicating NR-azo can respond to tumor hypoxia and correspondingly release NR-NH 2 .
quite significantqualifiedgold
Currently, however, most of the described biomarkers have limited clinical applicability, although at the same time they have quite significant uses in efforts to identify pathways associated with HF onset and progression.
Biomarkers in Heart Failure: A Review and a Wish.
Int J Mol Sci · 2025 · PMC12387009