“probable significance”

These methods are laborious and of moderate throughput, and thus will usually be applied to candidate CNEs that have already met some of the other criteria for probable significance.

The biological role of these POPs, although intriguing and of highly probable significance, remains less clear.

Elevated rates of gambling problems in type 2 disorder highlight the probable significance of modest but unstable mood disturbance in the development and maintenance of such problems. status released display-pdf yes is-in-collection-domain yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Received 2014 Jul 8; Revised 2014 Oct 31; Accepted 2014 Nov 3.

This finding points to a probable significance of DCX in ECM remodeling and crosstalk between leiomyoma and myometrium in this process.

These observations provided further support for the probable significance of cranberry oligosaccharides for UT health.

The dominance of the two size groups highlighted their probable significance in regulating biological processes. sRNAs from these size groups include heterochromatic siRNAs, which are 24 nt in length and function by means of RNA-mediated methylation of DNA targets [13] , as well as phasiRNAs and miRNAs, which can be of either length.

Pneumococcal DNA from NP samples [ 24 ] corresponding to ≥10 5 cfu/mL [ 25 ] by use of qPCR was also considered to be of probable significance.

We discuss the consequences of these differential gradients and their probable significance in instigating evolutionary adaptive behavior in the wax-nest building insects to utilize the same material for two distinction and functionally different purposes.

Because prostatic collagens accumulate with age, and because we did not observe a net increase in overall quantity of prostatic collagen producing cells, we consider the aging-related transition in the identity of collagen producing cells to be of probable significance with respect to prostatic collagen homeostasis.

The ongoing presence of Clostridium species in ASD populations, regardless of overt gastrointestinal issues, highlights their probable significance in the gut–brain pathophysiology associated with the disorder. 5.2.

We did a literature search about those drugs and their target genes to evaluate further the importance of those druggable targets and drugs and their most probable significance in COVID-19.

Increasingly, a well-trained PET/CT radiologist can provide advice on the probable significance of such findings, in conjunction with the clinical context.

The 30K bp of positive-sense, single-stranded RNA genome of SARS-CoV-2 encodes for 29 proteins, including the structural proteins: nucleocapsid protein (N), an envelope protein (E), membrane glycoprotein (M), spike protein (S) and nonstructural proteins; nsp3 (ribose phosphate), nsp5 (main protease), nsp10 and nsp16 (Mtase-methyltransferase), with their probable significance in the life cycle and pathophysiology of the SARS-CoV-2 [ 13 ].

Variants of probable significance were identified in LAMA2 and NDUFAF5 (Table 1 ).

Lastly, is the probable significance of the PC-CC candlesticks extending from the initial segment to the neuron perikaryon (Figures 4 B and 5 A,B), a peculiarity defined earlier in the isocortical (see De Carlos et al., 1987 ) and ammonic (Somogyi et al., 1983 ) CC.

Additionally, evidence of enzymes involved in steroid hormone metabolism in stromal cells of ovarian carcinoma ( 29 , 30 ), stresses the probable significance of sexual steroid hormones in the progression of this malignancy.

Estimated descriptors for various Amprenavir/HIV-1 PR systems ( Table 4 ) were normalized (0-100%) to elucidate their probable significance in achieving the optimum target conformation upon binding to Amprenavir (PDB ID: 1HPV).

Based on these definitions which may bring a much more clinically relatable understanding in MM prognosis, we aimed to assess our database regarding these two concepts and their probable significance in terms of outcome and prognosis.

These genes spanned functionally characterized categories, such as transcriptional regulation, disease resistance, and transport processes, underscoring their probable significance in MT-driven drought adaptation.

14) There is increasing suggestion in the literature that serum endocan levels can be used as an early biological marker of endothelial injury, as well as of its probable significance in determining arteriosclerosis and asymptomatic cardiovascular changes in the early stages. 15 – 17) In addition, higher endocan levels have been linked to insulin resistance and hypothyroidism. 18 , 19) Urotensin-II (U-II) is a cyclic 11Aa peptide first identified in the caudal neurosecretory syst

Additionally, the high isolation frequency of tbpA , followed by the pfhA , toxA , and hgbB genes, showed probable significance in the pathogenesis in sheep and goats [ 43 , 48 , 49 , 54 ].

The probable significance of this is referred to below.

The cytostatic effect of CCNU was also augmented by IRS and there was a slight augmentation of ICRF 159 which was of probable significance (Table II).

Another region of probable significance is the cysteine “cluster” of C124, C127, and C129.

The alternative hypothesis was accepted if probable significance was less than 0.05.