“nominally significant”

Of the nominally significant associations (0.00125 < P < 0.05), several reflect relationships that have also been reported previously, including associations between the ‘vigorous exercise’ factor and breast cancer 44 incidence for females and incidence of all cancers 45 for males (decreasing risks with higher scores), and between the ‘alcohol’ factor and bowel 46 and prostate cancer 47 incidence for males (increasing risks with higher scores).

While several features showed nominally significant correlations at uncorrected p < 0.05 , no features survived FDR correction at the 0.05 threshold, reflecting the moderate effect sizes and sample size constraints.

We took into account only those genes that reached significance (nominally significant p -value < 0.05).

All associations were performed in non-diabetic individuals and were statistically nominally significant at a level of P < 0.05 and adjusted for age, sex and ln BMI.

Eleven SNPs had ORs >1, and 5 from ADAMTS9 , WFS1 , CDKAL1 , JAZF1 , and TCF7L2 trended or had nominally significant evidence of T2D association ( P < 0.05).

We repeated the analysis using both prevalent type 2 diabetes at baseline and incident type 2 diabetes during follow-up. We estimated the power that our study had to observe a nominally significant association ( p < 0.05) of each individual SNP or the genetic predisposition score with type 2 diabetes, based on the expected effect size (and its SE) of each individual SNP or the score on type 2 diabetes.

Most local edges were consistent, though the edge between fruit and vegetable intake and aerobic physical activity showed a nominally significant difference at α = 0.05 level ( p < 0.05).

The MR-Egger (SIMEX) method yielded nominally significant ( P < 0.05) causal effects ( P = 0.032).

The associations remained nominally significant ( P <0.05) following an adjustment for intakes of other foods ( Table 2 ).

The sentinel variant rs62040020, which resided within an intron of Jupiter microtubule associated homolog 2 ( JPT2 ) on chromosome 16 (effect allele frequency (EAF)=10.6%), was measured in all six studies with a high imputation quality (r 2 >0.88 across all six studies) and was nominally significant (p<0.05) in four of the six studies ( supplementary table 2 and figure 4 ).

A “highly suggestive association” required a random effects model P value smaller than 10 −6 , more than 1,000 cancer cases, and nominally significant results in the largest study included ( P < 0.05). “Suggestive” associations had a random effects P value smaller than 10 −3 and more than 1,000 cases.

We defined significant novel associations as those nominally significant (p < 0.05) in the replication study and with an overall (discovery and replication combined) p value <5 × 10 −8 .

Nominally significant findings ( P < .05) that did not meet these thresholds were reported cautiously.

Considering only the biological N of 2 (two independent grow-ups of each strain, distinct from those initially screened in microarrays), and not the technical duplication of assays for each of those, 10 of the 18 genes assessed showed allele-dependent changes that were nominally significant ( P ≤ 0.05), whereas no more than one would be expected by chance (Table 3 ).

Although the association between rs4916251 and AAA was only nominally significant ( P < 0.05) in one of the cohorts tested (the AC), it is important to note that the AC was the largest study with the greatest statistical power, and that the meta-analysis estimate showed little evidence of heterogeneity ( I 2 = 13%).

By removing each SNP from the MR analysis sequentially, if the association is no longer nominally significant ( P > 0.05) with the SNP removed, this indicates that a particular SNP is driving the association.

236 (68.6%) of these 344 CpGs were nominally significant ( p < 0.05) in our study, while 22 (6.4%) remained significant after accounting for the multiple tests of the replication effort ( p < 0.05/344 ~ 0.0001) (Table 2 ).

Nominally significant associations ( p < 0.05) were observed between higher maternal levels of IL-8 during early pregnancy with lower gross motor (β: −0.902, 95%CI: −1.697, −0.107, p = 0.026) and fine motor (β: −0.880, 95%CI: −1.500, −0.259, p = 0.006) skills score at age one.

In the BMTI, 42 metabolite-mRNA pairs (19 mRNA→metabolite; 23 metabolite→mRNA) showed a nominally significant (p-value < 0.05) causal effect.

Evidence of 22 (51%) non‐genetic biomarkers exhibited a nominally significant effect ( p < 0.05) on AS, and 7 associations (14%) showed small‐study effects.

Several other associations were nominally significant (unadjusted P < .05), including weekly beer and cider intake (Neale Lab: OR = 0.038, 95% CI: 0.002–0.597, P = .020; MRC-IEU: OR = 0.059, 95% CI: 0.006–0.549, P = .013), bread intake (OR = 61.404, 95% CI: 1.558–2419.859, P = .028), salad/raw vegetable intake (OR = 0.012, 95% CI: 0–0.714, P = .034), and tea intake (OR = 0.169, 95% CI: 0.037–0.767, P = .021).

Polymorphisms in IL8, HIF1A, NR1lA, and VEGFA showed nominally significant associations ( P ≤ 0.05) with PFS and RR when compared with the wild-type genotypes.

Results: Among the 5 subjects, there were 132 nominally significant correlations (p< 0.05) between mRNA expression and MRI activity.

Variable Selection Based on linear mixed models including the factors of time, age at enrollment, sex, and stimulus version, 23 speech variables from the picture description task showed nominally significant ( P < 0.05) effects of time at the group level.

Among 204 exploratory pairwise correlations tested, 10 were nominally significant (p < 0.05).