“nominally significant”

They identified 10 SNPs in the GRB-associated binding protein 2 ( GAB2 ) gene on chromosome 11q14.1 with nominally significant associations ( P = 4.56 × 10 -7 to 8.92 × 10 -5 ) in the APOE ε4 carrier subset of the neuropathological discovery cohort composed of 299 LOAD patients and 61 controls.

Eleven nominally significant SNPs were identified within four novel genomic loci, including variants in FRMD3 (p = 5.0 × 10 −7 ) and CARS ( p = 3.1 × 10 −6 ), which were also shown to contribute significantly to time needed to develop DKD ( FRMD3, p = 0.02 and CARS, p = 0.01) [ 54 ].

The first of these regions is located on chromosome 2 and includes nominally significant SCZ variant (top variant in PGC: rs10189857, p = 5.14 × 10 −7 ) 19 in an intron of BCL11A , and a T2D risk locus upstream of the same gene (top variant in DIAGRAMv3: rs243021, p = 3 × 10 −15 ) 46 .

6, the text now reading “Numbers of SNPs that were nominally significant ( P < 1 × 10 −6 ) in the IPF GWAS meta-analysis and also eQTL” originally read “Heatmaps presenting the numbers of eQTLs that were nominally significant ( P < 1 × 10 −6 ) in the IPF GWAS meta-analysis” and has now been corrected in the HTML and PDF versions of the article.

No SNPs reached genome-wide significance, however four independent SNPs were nominally significant ( P < 1 × 10 −6 ) (Fig. 3 ).

To individually test candidate SNP pairs for interaction, we tested the nominally significant interaction results ( P < 1.0x10 -6 ) from the PLINK[ 63 , 64 ] epistasis test.

Supplementary Materials Supplementary Table 1: nominally significant genome-wide significant findings with a P value < 1 × 10 −6 .

29 To test for replication of hits from each study, we ran meta-analyses with each dataset individually excluded from the analysis and then queried significant and nominally significant SNPs ( p < 10 −6 , n = 45) from the excluded dataset in the meta-analysis results.

All nominally significant variants from each meta-analysis (p< 1.0 × 10 −6 ) are displayed in Supplementary Table 2 .

We found nominally significant overlap of epigenetic up- or downregulated H3K4me3 loci and loci harboring SNPs with suggestive associations (GWAS P < 1 × 10 –6 ) with major depression disorder (MDD) in the GDG set for the SZ14 ( P = 0.04) groups (Supplementary Table 11 ).

Of these, coeliac disease, rheumatoid arthritis, Sjögren's syndrome, and SLE, were classified as having highly suggestive (i.e., p < 1 × 10 −6 , at least 1000 NHL cases, and largest study in the review reporting a nominally significant result) or convincing evidence (i.e., p < 1 × 10 −6 , at least 1000 NHL cases, largest study in the review reporting a nominally significant result, minimal between‐study heterogeneity, and no evidence of publication bias) in the umbrella review [ 4 ].

Considering nominally significant SNPs associated with each trait with p < 1 × 10 −6 in either study, we find a strong, significant positive correlation (Pearson correlation = 0.92, p < 2.2 × 10 −16 ) between effect sizes in BioVU and ATLAS ( Figure 4 C).

There were, however, several nominally significant associations with p -values <1 × 10 −6 .

The top association signal for rs12671707 remained nominally significant in the 90 non-European panelists (effect size ± standard error = 28.48 ± 5.38; p-value = 1.14 × 10 − 6 ).

In the meta-analysis of all studies, a nominally significant association with LTL was observed with a rare variant in RPL8 ( p - value = 1.48 × 10 −6 ), which has previously been associated with age.

SNP rs116121322 in LRRC27 showed nominally significant association with POAG in the discovery cohort (OR = 29.85, P = 2E–06).

GTEx annotation of nominally significant SNVs by genome-wide association study identified enriched expression of genes in multiple tissues including the heart and lung ( P = 2 × 10 −6 and P = 6 × 10 −4 , respectively (Suppl.

Nominally significant associations were observed for the following health risk factors: Telomere length was longer among girls compared to boys (p = 3 e–06) and among children of high affluence families (p=0.008).

The minor alleles of the rs698195, rs3750552, and rs7275360 variants exhibited nominally significant associations with the allergic disease phenotype (rs698195: β=0.646, p =3.72×10 −6 ; rs3750552: β=1.33, p =4.40×10 −6 ; rs7275360: β=1.775, p =3.15×10 −6 ).

Genes with p < 0.05 were considered nominally significant; p < 3.77 × 10 −6 achieved genome-wide significance.

Of the approximately 12,000 OTU-phenotype associations considered, 3217 were nominally significant, and 149 OTU results surpassed the Bonferroni correction ( P = 3.90 × 10 −6 ).

Nominally significant loci ( P < 5 × 10 −6 ) were followed up for candidate gene mapping.

Further, there was no overlap with SNPs that were nominally significant ( p < 5.0 × 10 −6 ) for CRC‐specific mortality (Supporting Information S2: Table 1 , N = 144) or overall mortality (Supporting Information S2: Table 2 , N = 88).

Although SNPs with nominally significant (p<5×10 −6 ) associations with BDR are highlighted above, none reached conventional genome-wide significance, despite combined samples sizes of 10 623 EA and 3597 AA participants.

Mixed effects models were employed to evaluate the rate of change in Mini‐Mental State Examination scores as a quantitative measure of disease progression Results Variants on chromosome 22q12.1 mapped to ZNRF3, MN1, PIPNB genes reached genome‐wide significance and together with nominally significant loci ( p <5×10−6) highlighted a role for neuronal resilience (both excitatory and inhibitory neurones) and anti‐viral immune responses.