“nominally significant”

For instance, SNP rs113303918 in the intron of the FHL1 gene is significantly associated with WHR in female and the combined male–female analyses ( P XWAS, female = 6.6x10 –12 and P XWAS, combined = 9.8x10 –14 , respectively), while being only nominally significant in the male-specific analysis ( P XWAS, male = 4.5 × 10 –5 ) and the per-allele effect sizes on WHR are similar in both sexes (effect size ratio = 0.93, SE = 0.26).

Overall, SNPs with established marginal effects were overrepresented in the nominally significant part of the P v distribution ( P binomial <0.05).

The analyses identified four genes (FBXL5, GUSB, NRIP1, and RNASE6) that showed nominally significant inverse causal associations with IS and were therefore designated as key candidate genes.

There was no other nominally significant correlation between peripheral 5-HT system mRNA levels and ATD-induced changes in decision-making.

Both Ral and Las significantly increased the cortical bone thickness in the appendicular skeleton, whereas the effect of Bza was only nominally significant.

Nominally significant differences were reported in MDS‐UPDRS Part 3 for the low‐dose cohort and in Montreal Cognitive Assessment scores for the high‐dose cohort, but both used 80% confidence intervals without adjustment for multiplicity, limiting reliability.

There are however some OCR subsets that have an adjusted p-value < 0.05 with GREGOR and a nominally significant p-value with GoShifter (POL010.1_DCE_S_III, NRF1 and NFIA).

Firstly, we focused solely on nominally significant changes that were corroborated by multiple time points.

A previous study using LDSC to assess genome-wide genetic correlations (rg) found a low correlation between neurodegenerative GWAS datasets, with nominally significant positive associations between AD-ALS (0.19), AD-PD (0.23), and PD-ALS (0.23) [ 70 ].

46 found a nominally significant association between one single-nucleotide polymorphism (SNP) of GABRA5 and a symptom-based phenotype defined as ‘relative failure to initiate or sustain conversational interchange’ in the form of inflexible language behavior 47 .

After conditioning on adolescent BMI, most early-life associations attenuated, but inverse associations of BMI at 5 and 7 years with VATadj remained nominally significant.

Among 181 pQTLs without eQTL replication ( Figure 2a ), 61 had nominally significant transcript QTLs (PV <0.01; Figure 3a ).

Eighth, multiple comparisons were performed without formal correction; nominally significant findings should be interpreted accordingly.

The P -value < 0.05 was the threshold for nominally significant differential expression.

Here, we extensively compare the GWA results of the case-control and family-based designs using probands from the same population, and we attempt to replicate the initial association findings of many SNPs with nominally significant p-values in a two-stage process.

Second, no multiple testing correction has been applied; hence all associations are nominally significant at 5%.

Thus, in total, only 13 out of 31 variants were suitable for validation in the UKBB, 8 of which had nominally significant recessive associations to related phenotypes in the UKBB (Extended Data Fig. 5 and Supplementary Tables 6 and 7 ).

Two regressions were nominally significant (uncorrected).

All statistical analyses were performed using SPSS for Windows 18.0 (SPSS Inc., Chicago, IL) and associations with a p-value of <0.05 were considered nominally significant.

While several comparisons showed nominally significant differences before correction (e.g., Skoroszowice vs.

Proteins with an unadjusted p -value of < 0.05 were considered nominally significant.

Results Association study Of 14 selected genes comprising 43 SNPs, two SNPs in genes SELP and CAST showed nominally significant association with RA in the discovery set of French RA family trios ( Table S2 ).

The association between AN PRS and perfectionism showed nominal significance amongst females (OR = 1.12; 95% CI = 1.00, 1.25; p uncorrected = 0.04) ( Supplementary Table 3 ), while a nominally significant association between SCZ PRS and BE was seen in males (OR = 1.21; 95%CI =1.04, 1.40; p uncorrected = 0.01) ( Supplementary Table 3 ).

gene expression scores for schizophrenia To obtain an aggregate measure of transcriptional correlates of schizophrenia for each individual, we created a weighted sum of each individual’s covariate-adjusted gene expression values multiplied by the schizophrenia weights, using only the genes that had nominally significant differential gene expression in schizophrenia (as determined using the second model above).

For this variant, at least nominally significant eQTL effects in multiple tissues were detected using QTLbase [ 27 ]: In particular, eQTLs were identified in Induced Pluripotent Stem Cell for genes KLKB1 , CYP4V2 , F11 and in Blood-Macrophage for FAT1 gene .