“nominally significant”

In addition, several taxa were identified based on nominally significant IVW estimates with modest effect sizes; therefore, these associations should be interpreted as exploratory rather than definitive causal evidence.

A nominally significant relationship was observed between serum selenium levels and forearm bone mineral density.

Finally, through permutation analyses, we showed that the load score amongst coding sites had an excess of nominally significant associations on many medical phenotypes.

Indeed, fewer than half of the 32 SNPs in our panel are represented on any one high‐density SNP chip currently commercially available, although direct genotyping of a larger number of SNPs showing nominally significant association will be possible with the PsychChip (Illumina, San Diego, CA).

As evidenced by the eigenvector time series of PC1, the neural ensemble encoded a delay-discounted reward value (pointing toward –18°) in a stable manner for approximately 2 s after the presentation of the instruction cue and then rotated progressively toward a nominally significant pattern (pointing toward 44°) in which activity increased with longer delays to reward.

In the contrary, all-cause mortality was significantly lower under alirocumab, however, this finding is considered nominally significant as to the hierarchical testing with previous non-significant endpoints.

There were several nominally significant differences in neuroimaging and blood biomarkers differed based on participants’ gender, including water-referenced choline in the basal ganglia and IL-1β and YKL-40 in serum (though these associations did not survive FDR correction; S4 Fig ).

There were 3321 nominally significant differentially methylated CpGs in F0 sperm identified via WGBS with select methylation changes validated via bisulfite pyrosequencing.

Methylation level difference of gene segments and CpG sites between gliotic and florid PDR group Although no statistically significant differences were detected at the whole-promoter level for the 16 target genes between the two PDR subtypes, exploratory analysis of finer-resolution regions revealed several nominally significant differences at the gene segment and individual CpG site levels.

WHR and two skin fold measures (TrS and SbS) of cluster 2 also showed nominally significant associations with some of these markers, significance of which were not supported by the permutation test.

We next evaluated the probability of true association with cancer risk for the nominally significant variants through calculating the FPRP value.

While other connections had nominally significant differences, given the high dimensionality of the connectomes, they did not survive an FDR correction.

Of the 32 initially enriched pathways in MDD with hyperphagia, 22 were still nominally significant after BMI adjustment.

Despite the high negative correlation between HDL and very low-density lipoprotein (VLDL) or low-density lipoprotein (LDL) measures, only a few associations with LDL or VLDL measures were found nominally significant and none remained significant after correction for multiple comparisons.

The associations remained nominally significant after adjustment for major vascular risk factors.

In our sample, there were nominally significant differences between groups for cortical thickness and surface area in parietal and frontal brain regions; however these observations should be confirmed in independent studies before we can assess their role in the etiology of genetic risk for SCZ.

A two-tailed P < 0.05 was considered nominally significant.

28 An MYOC exon 3 variant (rs74315329; effect allele: A) was associated with a 1.63 mm Hg (95% confidence interval [CI] = 0.64 to 2.64) and 2.67 mm Hg (95% CI = 1.7 to 3.60) increased IOP in participants <51 years old and ≥63 years old, respectively, resulting in a nominally significant age-gene interaction ( P interaction = 0.05; Supplementary Table S10 ).

The marker pair on chromosomes 1p and 2q, which gave a Z score of -4.08 in Mexicans, also had a nominally significant Z score in Puerto Ricans (-2.40), while the pair on chromosomes 1p and 17p (Z score of -4.09 in Mexicans) also had a nominally significant Z score in Puerto Ricans, but in the opposite direction (Z = +2.42).

The autophagy enrichment was nominally significant in the primary analysis but did not survive Benjamini-Hochberg false-discovery rate correction across the ten tested pathways (false discovery rate (FDR)-adjusted p = 0.41979); the findings should therefore be considered hypothesis-generating. autophagy cellular maintenance genetic architecture hyp

MR Results with the P FDR < 0.1 were considered significant; whereas results with p < 0.05 but P FDR > 0.1 were considered as nominally significant.

Also, we regarded p < 0.05 as nominally significant.

15 , 20 Meanwhile, in patients previously treated with ruxolitinib (SIMPLIFY-2), there was a nominally significant difference in favor of momelotinib versus best available therapy (88.5% ruxolitinib) in MPN-SAF TSS. 16 Because the threshold for superiority for the primary end point (splenic response rate [SRR]) was not met, symptoms could not be formally assessed.

Using 109 selected tagging SNPs localized within TP63 with a minor allele frequency >0.01, they found nominally significant associations between BEEC and six SNPs and four haplotype blocks including or near these significant SNPs; however, none of these results remained significant after correction for multiple testing.

We observed that 7 of these pairs had a nominally significant association p -value p< =0.05 in CAMP.