“nominally significant”

However, P < 0.05 was assumed nominally significant of a causal association.

Effect sizes were modest for these nominally significant findings.

For sleep midpoint, a nominally significant association was observed with knee osteoarthritis (OR (95% CI) = 0.52 (0.36 to 0.74), P IVW = 0.0004, FDR = 0.018), and hip and/or knee osteoarthritis (OR (95% CI) = 0.65 (0.46 to 0.93), P IVW = 0.017, FDR = 0.248).

Finally, the tendency toward associations being nominally significant, but not significant after multiple testing corrections, may be a result of the smaller sample size.

For example, of the total 1,297 genes with a nominally significant gene-based p-value (Pgene-based ≤ 0.05) in the MA subgroup, 132 genes also produced Pgene-based≤ 0.05 in the MO subgroup.

After covariation with total tau, we found seven nominally significant markers in plasma and one nominally significant marker in CSF.

For region-level analyses, given the 816 MR estimates, a Bonferroni-corrected P -value was set as 0.05/816 (6.127 × 10 −5 ), and meanwhile P < .05 was regarded as nominally significant.

Over a (median) 18-year follow-up period (1993–2016), conjugated equine estrogens nominally significant reduce for coronary heart disease, breast cancer, hip fracture, and all-cause mortality.

Conditional logistic regression of the combined dataset demonstrated nominally significant association of JIA with lower methylation at CpG_9, such that a 1% increase in methylation equates to a 6% decrease in risk of being a JIA case (OR = 0.94, 95% CI: 0.87, 1.00; p = 0.064).

In contrast, extending SNP inclusion to the genome-wide nominally significant variants substantially improved predictive accuracy [ 47 ].

When cancer sites were more finely divided, a nominally significant excess of female breast cancer was observed (31 [3·0%] vs 17 [1·7%]; along with four vs one male breast cancers), but that difference is based on small numbers of events and was not significant after appropriate allowance was made for multiple comparisons (as prespecified).

Several additional genus–host marker associations, including correlations involving lymphocyte percentage and neutrophil percentage, were nominally significant but did not survive FDR correction and were therefore interpreted as exploratory signals only ( Figure 5C and Supplementary Table S4 ).

A GRS of 10 POAG lead variants identified in European-descent GWAS was only nominally significant in African American prevalent cases.

In CUPID B, the change in UAS7 was statistically significant (EU hierarchy)/nominally significant (non-EU hierarchy); ISS7 at week 24 did not meet significance; and Weekly Hive Severity Score (HSS7) at week 24 was nominally significant.

Due to the large number of association tests performed, there will be many nominally significant results.

A subsequent pathway analysis (enrichment and topological) of the significant metabolites resulted in three nominally significant enriched pathways for contact allergies and one pathway for hay fever that are displayed in Table 5 . 3.7.

Nominally significant differences that did not withstand FDR correction are shown in Fig. 1 and should be interpreted cautiously.

This study found no genome-wide statistically significant associations ( P < 5 × 10 –8 ); however, TMEM132D , LRRC7 , and STIP1 were identified as nominally significant [ 109 ].

Other nominally significant associations with the RR for the primary end point or for mortality occurred for the following: rate of crossover from experimental to control group (Figures S4 and S5 ); CABG trials; and trials allocating more invasive treatments to the experimental arm.

Click here for file Additional file 9: Table S4 Detailed results for the 10 most nominally significant interactions.

Although one CpG site was found to be nominally significant, we did not consistently replicate the direction of this association.

These findings were nominally significant and withstood sensitivity analyses, showing no substantial heterogeneity or pleiotropy.

A list of all nominally significant SNP-QT associations is provided in Supplementary Table S6 .

Repeated-measures analysis of covariance (ANCOVA) revealed nominally significant time-by-group interactions in the left posterior orbital gyrus (POrG), left posterior insula (PIns), left subcallosal area (SCA), and left transverse temporal gyrus (TTG), with only the left POrG remaining significant after false discovery rate (FDR) correction.

Furthermore, despite the limited statistical power of our sample size, we did observe a nominally significant association at rs138269346 COL4A1 for nonlobar ICH risk.