“nearly significant”

We did not investigate the effect of IL28B -860 SNP as a co-factor as we did not find nearly significant evidence of this trait clustering on any of the phylogenies.

HER2 YVMA overexpression in 4T1 models led to a nearly significant increase in the frequency of spontaneous brain metastasis, with 1/5 HER2-negative mice developing metastasis compared to 8/10 across the HER2-expressing groups (Fisher’s Exact Test p = 0.0889).

Gomez-Saez et al found that cancer risk was associated with smoking habit, nodule size and spiculated edge which was nearly significant and there was a linear relationship between nodule size and risk of lung cancer [ 35 ].

Dried samples were diluted in the same manner as described in (c) with one difference: due to the non- or only nearly significant results for R . variabilis in 2012 we doubled the concentration of both the total sample as well as the fractions of this species used in 2013.

In our study, smoking was a nearly significant risk factor for overall survival in univariate analysis (HR(95%): 2.63(0.91–7.63), p: 0.07).

Discussion In this study, we investigated the influence of the OAT6 and OATP1B1 inhibitor probenecid on sorafenib pharmacokinetics and toxicity in patients, and found a significant decrease in the geometric mean of sorafenib plasma exposure and a nearly significant decrease in intracutaneous sorafenib exposure during concomitant probenecid administration making sorafenib concomitantly with probenecid not bioequivalent to sorafenib monotherapy.

In children with an age at diagnosis less than 8.5 years significant or nearly significant differences were seen in two verbal subscales and one nonverbal subscale, as follows: arithmetic, a verbal task that measures immediate memory and focus; requires the ability to perform mathematical calculations.

In examining the higher-order epistasis present in our datasets, we noted that the clusters where significant epistatic volumes occur are often preceded in lower dimensions by clusters with nearly significant epistatic volumes ( SI Appendix , Fig.

In contrast, healthy controls showed a nearly significant decrease of the urge to drink alcohol after applying the protocol with a high number of repetitions.

Interestingly, we found that among all tissues examined, the breast mammary tissue showed the strongest statistical evidence for non-random connectedness among breast cancer genes (p = 0.0015), and this result was nearly significant after Bonferroni correction (p corrected = 0.07).

Lastly, inactive subjects had nearly significant negative correlations between FCV and SFC at rest and significant negative correlations during the task ( Figure 6B , bottom row).

Indeed in a prior study in which initial learning was carefully examined, cocaine-treated rats showed a small but nearly significant improvement in acquisition of the initial discrimination problem learned (Schoenbaum et al., 2004 ), and we have observed a similar facilitation in accumbens-lesioned rats (Schoenbaum and Setlow, 2003 ).

There was no well-differentiated tumour in total PSA positive patients while 26.8% of the negative patients had well-differentiated tumours, the difference was nearly significant. In total PSA positive patients compared to negatives, there was a tendency to be in advanced stage disease and lymph node metastasis.

Nearly significant differences were observed for BMI and waist circumference between the rural and urban groups, indicating higher BMI among urban residents (Additional file 2 ).

In order to check whether this correlation could have been driven by the (nearly significant) discrepancy in the verbalizer scores reported by the two groups, a partial correlation, controlling for visual status, was performed.

In the present study, C-reactive protein levels had a nearly significant effect on increasing the probability of low functional strength.

Upon examining the tumor tissue, a continuous and nearly significant increase in absolute B cell total count was revealed in the tumor group from day 14, reaching its peak on day 21 ( Figure 1 C).

A prospective power analysis was not performed to determine an appropriate sample size, but our small sample size likely makes the study underpowered, a conclusion supported by several nearly significant correlations.

pulex or Ceriodaphnia density in any of the four experiments, (though there is a nearly significant negative trend in Experiment 2 on Ceriodaphnia ).

The two nearly significant SNP markers on A5; Bn-scaff_16893_1-p69538 and Bn-A05-p18820057 at 16.76–17.25 Mb for RDW at LP, were detected in both systems employed in this study ( Supplementary Fig.

In the above mentioned series, the CA genotype at position −592 of the IL-10 gene promoter has been associated with a nearly significant higher frequency of liver cirrhosis in bivariate analyses [19] .

Consequently, significant and nearly significant findings might be worthy of additional study in a larger group of dogs.

However, mice on NAF did have statistically elevated levels of liver TNF-α and nearly significant levels of IL-6, but no difference in IL-12p40 or IL-10 ( Figure 1(h) ).

This result was not statistically significant, but it was nearly significant.

Results The results indicated four peptides had significant or nearly significant seropositivity, and all of them were associated with the S and M proteins.