Barely Significant
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“near-significant”

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Listed by Otte et al. (2022)

In the literature

Genes displaying this trend with significant increases in all comparisons ( p < 0.05, Wilcoxon rank-sum test) or near-significant increases included known key immune/interferon response genes ( AIM2 , CLEC5A , CTSD, FCGR1A , FCGR1B , IFI16 , PSMB8 , SP100 ), stress/chemical response-associated heat-shock chaperonin protein HSPD1 , Krüppel-like factor transcriptional regulator KLF4 , and mitochondrion-associated genes CISD1 (CDGSH iron sulfur domain redox-active protein) and MTHFD2 (methylenetetrahydrofolate dehydrogenase).
Nevertheless, the near-significant trend towards a higher ICH rate in the intravenous rt-PA group warrants caution and highlights the importance of individualised risk assessments and close monitoring for elderly or high-risk patients when considering intravenous rt-PA therapy.
Effects of NO 2 and ETV on asthma Univariate ORs for the seven candidate NO 2 exposure periods indicated that a 1-SD increase only in year-of-diagnosis NO 2 (4.3 ppb) showed near-significant associations with asthma for the full cohort [OR = 1.17; 95% confidence interval (CI), 0.94–1.46], and was used going forward as our key exposure metric.
The RR further increased to 1.80 (95% CI: 0.94, 3.45) for those living within 100 m of a drainage path and with household food animals compared to those >500 m from a drainage path and without household food animals; this interaction was near-significant with an interaction P -value of 0.108 (RERI: 0.85; 95% CI: −0.10, 1.81) ( Table 5 ).