Discussion Our study demonstrates that periodontal inflammation (measured as BOP) and severity (measured as PIRIM) are associated with a higher cardiovascular risk, measured by LDLC, HDLC, CRI-1, CRI-2 and a near-significant association between PIRIM and AIP.
However, the titer of just one metabolite, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), displayed near-significant enrichment in Hamiltonella -positive aphids in both metabolome experiments.
All relevant predictor variables were entered into an initial regression model and then a second model was tested, involving only statistically significant and near-significant predictors.
In the present study, the absence of enhanced performance of prebiotic groups, as well as their near-significant reduction in BW on day 14, may reflect mismatches between substrate availability and microbial adaptation: in the sequential GXOS diet group, early GOS exposure may have primed communities that then required additional time to adjust to XOS, delaying microbial shifts and subsequent XOS-mediated performance benefits; conversely, in the XOS group, introducing XOS after seven days of the basal diet may have disrupted the stabilising microbial community, requiring a reorganisation of established cross-feeding networks and imposing short-term metabolic costs that limited growth efficiency.
In addition, the SNP-based linkage analysis identified a near-significant region of 0.19 Mb on Xp22.33, that spans the boundary between the pseudo-autosomal region and the X specific region (LOD = 2.94, figure 2 ).
Support of Expression Studies for Suggestive SNP Associations Incorporating previous gene expression data can improve the value of GWAS data, especially when significant expression data coincides with suggestive (near-significant) SNPs ( Cheng et al., 2013 ).
A near-significant treatment effect was observed for plasma corticosterone concentrations following the four acquisition days and probe trial.
High dietary fats as a part of the HFD upregulated genes that support fatty acid oxidation, such as carnitine palmitoyltransferase Ib ( Cpt1b ) and phosphate carrier Slc25a3 (imports of phosphate into the mitochondrial matrix), as well as mitochondrial dysfunction via BCL2/adenovirus E1B interacting protein 3 ( Bnip3 ) in the near-significant 1.84- to 1.92-fold range ( Figure 5 a).
A near-significant difference was also found in ID among quartiles, while no significant difference was found in MIP values.
No statistically significant differences were found among the subgroups, though there was a near-significant difference in age.
Furthermore, compared with the control, Bacteroides -gavaged mice exhibited significantly decreased systemic glucose intolerance and near-significant improvement in insulin resistance, as revealed by the results of the 1-g oral glucose tolerance test and insulin tolerance test ( Figures 4 D and 4E).
Patients’ medication-related concerns did not contribute significantly to subgroup membership, whereas a near-significant association was found between patients’ beliefs about medication necessity and their membership of the benefit-driven subgroup (RRR: 1.12, 95% CI: 1.00–1.23).
The closest estimate being comorbid depression at baseline which was found to have a near-significant association with ASRS change, such that depressed participants showed less improvement in self-reported ADHD symptoms over the course of treatment.
Similar patterns were observed for PROMIS pain interference, with greater improvements in the sublaminar group at the 2-week and 6-month time points, and a near-significant difference at three months.
However, despite our large sample size we were able to estimate the effect of uncommon predictors on uncommon outcomes with less precision, potentially resulting in some false negatives and near-significant results.
There were no significant differences among the cardiorenal outcomes, although there was a near-significant tendency to higher risk of CKD in T1D, HR 1.43 (0.97–2.11).
The near-significant associations of these functionally relevant genes suggest that they may contribute to OCD pathophysiology through disrupted ion channel function and neuronal excitability.
This near-significant threshold highlights a direct dose–response relationship, indicating that greater absolute activation of the expansion appliance yields a corresponding volumetric and spatial advancement of point A.
However, the study noted site-specific associations, particularly an elevated risk of prostate cancer among non-tobacco smokers who used cannabis and a near-significant increase in cervical cancer risk.
One challenge with this method is how to treat near-significant interactions.
Metabolites that were repeatedly retained across cross-validated LASSO models and remained significant or near-significant in the refitted model were prioritized for inclusion in the final diagnostic panel.
The results indicated a weak but near-significant trend showing that individuals with more favorable attitudes tend to have higher levels of knowledge.
Similar to our findings, TG levels exhibited a near-significant association with aortic stiffness, whereas TCH levels did not.
Analysis of Likert scale ratings across all five didactics within separate gamified and traditional cohorts demonstrated, in both cohorts, significant or near-significant increases from pre-test to post-test in ratings of confidence and knowledge of guidelines.
Although not statistically significant, the near-significant trend with cardiometabolic health aligns with emerging evidence linking poor oral health to systemic inflammation and cardiovascular risk [ 50 ].