The near-significant enrichment of these pathways in metabolomics alone may reflect broader metabolic perturbation associated with the inflammatory state; however, their lack of transcriptomic support limits the evidence for their direct involvement in the gene-to-metabolite regulatory cascade explored in this study.
Additionally, when the control group used a placebo (p = 0.07), although there was no significant difference in the treatment effect of extracorporeal shock waves, this near-significant finding might suggest a potential therapeutic effect.
Near-significant trends for winter weekend and holiday time in the sun showed no such trends when ambient UVR was accounted for in UVR-load parameters.
Pesticides remained significant (or in one case, near-significant) in each model.
To maximize the speedup, we recommend always specifying a p -value threshold and using pulver as a filter to find models with significant or near-significant interaction terms.
However, in addition to the infants below one year of age, the initiation of SAT at the age of >1–≤2 yr was found to be a dependent risk factor ( p < 0.01) and a near-significant independent risk factor ( p = 0.09/0.10) for progression after 3 and 5 years.
In blood proteomics, one significant protein (PEAR1) and three near-significant proteins (NDE1, EVA1C, B4GALT2) were identified, but lacked colocalization evidence.
Although previous TMS studies have reported no or only near-significant increases in amygdala volumes in adults with MDD ( Furtado et al., 2013 ; Hayasaka et al., 2017 ) and TRD ( Dalhuisen et al., 2021 ), smaller pretreatment right amygdala volume has been associated with greater improvement in depressive symptoms with TMS treatment ( Furtado et al., 2013 ).
In contrast, diabetic participants exhibited a near-significant difference in BMI across tertiles ( P ═ 0.082).
There was a near-significant interaction between SES and group for rating of physical activity importance, with adverse effects of the intervention only being seen for the higher SES families, and virtually no group differences in the lower SES families.
No significant or near-significant sex effects were observed in the molecular data, so those data were analyzed with both sexes combined by condition. 3 Results 3.1 Maternal weight Maternal weight was analyzed with a linear mixed model with a random effect of rat ID to account for repeated measures.
A near-significant difference in barb density was found between populations, and the change between populations was unrelated to sexual dimorphism in tail length ( Table 3 , Fig 4C ).
The near-significant p -value is due to the relatively high nerve scores among subjects with idiopathic hearing loss compared to subjects with known non-ANSD etiologies.
Notably, the DST results showed a near-significant impact on histopathological malignancy markers (eg, Ki67 index) and the risk of metastases or recurrence, suggesting potential links to tumor aggressiveness that warrant further investigation.
Furthermore, the combination of TM (1.3 and 2.6 μg/mL) with ZYM resulted in a significant or near-significant increase in the expression of CCL20 for all ZYM concentrations tested.
We did note, however, the near-significant survival advantage for DNR-90 and IDA-12, in the younger age group, even after adjusting for age and karyotype ( Figure 1B ).
A near-significant increase in associated tumours was found. pmc-status-qastatus 0 pmc-status-live yes pmc-status-embargo no pmc-status-released yes pmc-prop-open-access yes pmc-prop-olf no pmc-prop-manuscript no pmc-prop-legally-suppressed no pmc-prop-has-pdf yes pmc-prop-has-supplement no pmc-prop-pdf-only no pmc-p
This revealed significantly elevated GLP-1 content in the hypothalamus (a major PPG neuron projection target) in the obese state, with near-significant increases also observed in brainstem and spinal cord ( Fig 6 C).
LVEDD, r = –0.621, P < 0.05) as well as a near-significant correlation with EF ( CALCOCO2 vs .
A valuable approach to improve statistical rigor would be to re-examine these near-significant miRNAs in expanded populations to evaluate their reproducibility and potential additive effects when analyzed in combination.
A near-significant difference was found between pigs fed chicken combined with prudent background diet (1.54 Mm) and pigs fed red meat combined with western background diet (3.38 Mm) (Tukey’s HSD test, p = 0.06).
The results indicated that there were significant and near-significant differences in the cortical bone between these two strains.
If the four models for the unaware respondents ( Tables 2 – 5 ) are compared with an equivalent set of models where all participants are included—without an interaction term for guise and awareness —results look decidedly different, indicating a significant or near-significant effect for Guise for all locales (see Tables A9 – A12 , in the Appendix , section “Further Results of Mixed-Effects Models,” see also Figure 1 , lower graphs (b)).
A near-significant phenotypic correlation was found between gray matter and Sz (r ph = −.08, 95% CI: −.16 to .00).
Valencian Community, Cantabria and Navarre showed significant or near-significant increases after the intervention (Beta intervention).