“near significance”

The five of six miRNAs (miR-93-5p, -19a-3p, -22-3p, -362-5p, and -210-3p) which found significance or near significance by qRT-PCR each target one of four genes of interest to us (CSF-1, CSF-1R, ErbB4, or HIF-1α).

Acetic acid (SMD = – 0.37, 95% CI: 0.77 to 0.03, p-value = 0.070) and hexanoic acid (SMD = −0.53, 95% CI: −1.09 to −0.03, p-value = 0.060) also showed a lower trend in the depressed group, although only near significance.

Rheumatic diseases Rheumatoid arthritis RA was diagnosed earlier by 1.3, 0.6 and 1.3 years, after adjustments, in South Asian, African-Caribbean, and Mixed-race/Other groups, respectively, in comparison to the White group, although only reaching near significance for the South Asian group (Table 3 ).

It should be noted that the differences found in the use of vitamins (.06) and chiropractic medicine (.08) were near significance at the .05 level by race; perhaps, with a larger sample size, significant difference may have been obtained.

However, near significance was reached when exploring the association between diabetes, high BSL and in participant who spNES.

We ran the best-fitting models again with the insertion of the FB prohibition variable in order to assess whether its p -values in any of the models was near significance.

Other lectins showed near significance for binding more B4 compared to Q0.

This is also corroborated by the positive correlation between UTF1 methylation and expression in 2 cell lines (A431 and HeLa) of the 4 that were treated with 5-aza, with a third cell line (CaSki) being near significance.

PNS was not significantly related to odds of reporting poor subjective sleep quality, but did near significance in the urban sample, where participants who feel safer in their neighborhood tend to have lower odds of reporting poor sleep.

The loss of many teeth did not result in an elevated risk of liver cancer mortality in a study involving Swedish adults (hazard ratio 1.26, 95% confidence interval 0.55‐2.90), 10 but risk of death from liver cancer was near significance in an elderly Japanese cohort (hazard ratio 1.07, 95% confidence interval 0.98‐1.17). 56 Only 13 deaths from liver cancer were recorded in this study. 11.3.

Deconvolution of the UMAP data revealed that “Male Cluster 1” was characterized by higher levels of CCL20, CCL4, CCL5, CXCL2, IL-6 (near significance) and VEGF compared to individuals in “Male Cluster 2” ( Figure 7E ).

However, full IQ had only a near significance correlation with brain atrophy.

A fourth category, demonstrating responsibility , was near significance (ASR = 1.91).

The Threat versus Safe slowing effect was only significant at CSI 700 ms ( p = .0070) but was near significance at all CSIs above 200 ms ( p s < .063).

The CRT protocol was effective for the significant decrease of BMI, SBP, DBP, CVD risk index and an increase of SpO 2 near significance.

Despite being near significance, the relationship between long-term improvement in omission errors and improvement in BDI scores in the MDD group was not significant ( r = 0.442, n = 13, and p = 0.113). 4.

While the statistic suggests near significance of the effect of behavioural conditioning in animals treated with laminarin 1 hr prior to training the results leave no doubt (see Figure 3 A2) that, in contrast to the animals trained 24 hrs after treatment, the impact of training in this group is drastically reduced compared to their vehicle-injected counterparts (F 1,126 = 22.481, p < 0.0001 for animals trained 1 hr post-treatment and F 1,32 = 0.001, p = 0.98 for animals trained 24 hrs post-treatment).

Interestingly, our data indicate that age alone was not a significant predictor for improvements in clinical outcomes, although advanced age did near significance predicted less improvement in VAS neck and VAS arm.

Another granulocyte population with near significance were the increased proportion of eosinophils in the opioid-exposed group (Fig. 1h ).

13 In a multicentre study, living near dense traffic was associated with a lower FEV 1 and FVC in women, while in men only age-adjusted means of FEV 1 were lowered to near significance. 14 In a multicity study, women living near dense traffic had a lower mean FEV 1 and FVC and increased risk of COPD. 15 However, other studies found no associations between living near a road with dense traffic and FEV 1 or other measures of respiratory morbidity. 16 In individuals with obstructive lung disease, high exposure to dense traffic was associated with airway restriction, with a significantly lower FVC than for the low-exposed individuals in the same group.

To determine whether this variant in CPB2 was independent of the two more common amino acid substitutions, we instead conditioned on Thr147Ala (rs3742264) and Thr325Ile (rs1926447) and found that the variant remained significant ( P conditional = 1.66 × 10 −6 ), suggesting that the observed rare variant associations are distinct from known SNPs. In contrast to intact TAFI, for TAFI-AP SKAT-O yielded significant gene-level associations with five genes ( Table 3 ) and only near significance with CPB2 ( P SKAT-O =7.18 × 10 −6 ).

Deprivation and having prostate cancer were near significance and were therefore also included in the multivariate analysis. 3.3.

Among up-regulated DEGs, protein processing in endoplasmic reticulum (ko04141) was the only pathway near significance (5 genes; q = 0.058), including the membrane-bound site-2 protease S2P ( GME2708_g ; log 2 FC = 1.04) and four HSP20 family genes ( GME10364_g , GME10368_g , GME10370_g , GME6432_g ; log 2 FC 1.07–1.56) ( Figure 4 C).

The significant association between amyloid‐PGS and A+, and near significance after adding the APOEscore, demonstrates the existence of additional genetic effects outside of APOE that have an impact on amyloid accumulation.

Considering the positive valences, i.e., peppy/enthusiastic, glad/cheerful and calm/serene, glad/cheerful negatively correlated with RMSSD (near significance was observed with pNN50) and calm/serene negatively associated with mean RR Interval.