“might be significant”

Conclusions The study of miRNAs’ functions has revealed a new regulatory layer that might be significant given the amount of missing information about the genetic and epigenetic variability in the etiology and pathology of human diseases.

However, there might be significant uncertainties and debatable assumptions in the input data, especially for emerging pathogens.

Therefore, we speculated that the functional differences in MBD genes among different branches might be significant, indicating that the functional differences among MBD proteins were gradually realized during the evolutionary process.

Thus, identification and characterization of the functional roles of dysregulated lncRNAs in GBM and their underlying mechanisms might be significant for cancer research, and helpful for finding novel therapeutic targets.

It contains two collagen genes (COL11A2, COL2A1) several solute carrier genes (SLC8A3, SLC13A5, SLC36A2) which have been shown to be prognostic in osteosarcoma 54 , and genes involved in Wnt signaling (APCDD1L, BARX1) which might be significant given the oncogenic role Wnt signaling plays in osteosarcoma 55 , 56 .

The only exception to this could be kNN because kNN's classification time grows linearly with the size of the training set, which might be significant larger in the actual application than in our study.

This bias might be significant in patients with falling or jumping from height as their trauma mechanism because this trauma mechanism can include pronounced amounts of patients with mental health problems or substance misuse.

Conclusions Our study described rare diseases in Chinese patients and our results enrich the phenotype spectrum of related diseases, as well as mutation spectrum of related genes, which might be significant for clinical disease diagnosis and prenatal diagnosis.

This variance suggests there might be significant intraindividual fluctuations in purpose over short periods of time.

Such encoding occurs continuously as part of everyday life, typically without advance knowledge as to what in the vast amount of material being surveyed might be significant on a later occasion.

In other words, if an epithelial cell is never at +40 or -80 mV, then the I-V properties of TRPC6 at those membrane potentials simply don’t matter for that cell (but might be significant for a different cell type).

This suggested that, during the pronunciation of certain fricative sounds, maintaining a slight interocclusal distance might be significant, indicating that the VD could be related to the functional requirements of speech [ 18 ].

It might be significant in this regard that the N-terminal domain contains a putative coiled-coil region, a feature utilized commonly for the oligomerization of proteins ( 36 ).

The results of our study might be significant for developing effective strategies for preventing frailty and promoting healthy aging for middle-aged and elder adults.

Even as technological progress has reduced power consumption for each sensor, the number of such units in sports applications might be significant.

Mechanistically, it might be significant that high histamine concentrations in patients suffering from coronary heart disease were noted in the blood.

Based on studies reporting the relationship between adaptive immunity and insulin resistance, we hypothesized that there might be significant differences in CD8 + and CD4 + T cell immunity in the blood between children with and without MS.

Another possible reason is that because the DoC patients are heterogenous, the difference in treatment effects between patients might be significant.

Also, these nucleoid dynamics might be significant in the role for CrfC in chromosome partition.

Likewise, diff-reg sncRNAs that are not miRNAs might be significant mediators of pain variability.

The resting potential with the K-free internal solutions was in the vicinity of zero, so it seemed possible that there might be significant K entry before the axon was clamped to the holding potential.

Since the incidence of IES-positive cases in perihilar eCCAs was low, most of the IES-positive cases in previous studies were invasive IPNBs, and IES-negative cases were conventional perihilar eCCAs; therefore, the differences in patient outcomes might be significant.

It should be pointed out that for a long-lived triplet state that is formed with high quantum yield ( Table 1 ), self-quenching of the triplet state might be significant, i.e. that the observed triplet state lifetime might be concentration dependent.

What adaptations might be made to any given option and could they alter its benefits, harms and costs? The penultimate step in characterising the costs and consequences of an option is to determine whether there might be significant interest in, or pressure, to adapt an option that has been tried elsewhere.

However, there might be significant changes in the eCB receptor expression and activity in the brain as were shown in animal studies ( de Chiara and others 2010 ; Di Marzo and others 2009 ; Gomes da Silva and others 2010 ; Zhou and Shearman 2004 ).