“might be significant”

Adverse events may be serious or otherwise; the former are defined as those which “might be significant enough to lead to important changes in the way the [intervention] is developed” [ 79 ].

The years 2001–2002 thus represent a period when patients were beginning to act on this information, and there might be significant racial/ethnic differences in patient responses based on access to information and the nature of decision-making complexity.

For the other residues, the side chains are in contact with the antigen; therefore, their contribution to the direct interaction might be significant.

Since hypertension is the main reason for the increase of neural loss and deterioration of brain performance, therefore evaluating the degree of neural apoptosis at early stage of hypertension might be significant to minimize the subsequent complications.

4 A possible explanation for this discrepancy might be significant under-reporting of lead malfunctioning.

Over long periods of time, even rare exchange might be significant and cause enough mixing of the genomes that we were not able to detect genetic differentiation between subpopulations.

The clinical implications might be significant.

4 , 5 Once the interpreter is familiar and has more experience with VCE, the time spent in VCE evaluation might be significant in increasing diagnostic accuracy. 6 , 7 In this issue of Clinical Endoscopy , the Korean GUT Image Study Group and their colleagues investigated the learning curve of VCE for beginners. 8 They postulated that although VCE has become an important tool for the diagnosis of small bowel diseases and can be performed without technical skill, the images should be interpreted by someone with experience in gastrointestinal mucosal image assessment.

In addition to environmental factors, recent genome-wide association studies revealed that genetic and epigenetic abnormalities might be significant determinants of HCC or PC susceptibility with important influence on the individual predisposition to disease progression, e.g. chronic inflammation, and resulting carcinogenesis.

[ 13 ] indicated that the characteristics of flexibility of sleeping habits and the ability to overcome drowsiness might be significant influencing factors of adaptability and tolerance to night work.

The decreased SDF-1 levels under statin therapy might be significant because this could potentially reflect altered endothelial repair or regenerative activity.

Such clinical observations might be significant for gaining an in-depth understanding of changes at the cellular level in TK.

The number of setbacks might be significant if the spread and dominance of illnesses are widespread.

A third possible diversification pathway is proposed, where neither P167S nor D240G were selected in the first stage of the process, and where neutral drift might be significant in the initial steps.

Generally, workers in a wide range of workplaces may expose to benzene and this exposure might be significant in oil processing industries, polymer or resin factories, rubber production facilities, and gasoline stations, oil processing industries, polymer or resin factories, rubber production facilities, and gasoline stations [ [1] , [2] , [3] , [4] ].

also reported that low mean ADC values might be significant in predicting the high malignant potential of GISTs [ 28 ].

In conclusion, the risk of drug-drug interaction might be significant among patients taking AEDs and DOACs simultaneously, at least for some AEDs; future studies will help to better quantify this risk and to facilitate an optimal therapeutic handling of these patients.

This might be significant because Akkermansia is known to enhance gut inflammation and in doing so may enhance infections caused by S . enterica [ 32 ].

Preclinical models effective in studying molecular mechanisms by which estrogen stimulates tumor proliferation and development of endocrine resistance in ER + breast cancer have concluded that the cross talk between growth factors might be significant in development of resistance to therapy [ 26 ].

Given the high level of heterogeneous GagPol expressed under the strong TEF1 promoter in the context of the high copy number 2-micron-based plasmid, competition for cellular resources between the inherent virus and an additional replication-competent structure might be significant, resulting in the rapid loss of selective pressure-free counterpart LA-1 dsRNA.

As the most significantly enriched gene with high degree of connectivity, dysregulation of SIRT1 expression might be significant in HUVEC exposed to HDP.

Consequently, when comparing the effects of IOF protocol among the participants of the investigated population, there might be significant differences in effects of IOF training due to possible inter-individual and intra-individual differences in responses of the participants to that kind of treatment.

The issue of the experimental observation of negative refraction was then raised for these water-based metamaterials 19 , since the energy attenuation might be significant in these metafluids due to the intrinsic absorption in the porous micro-beads, and to the strong resonant scattering by the particles.

Other mechanisms related to efflux pumps might be significant in the development of clarithromycin resistance[ 10 , 42 ].

The problem that was succinctly expressed by Levy and Duke (2003) still exists: that many movement analysis systems are designed to gather easily quantified empirical evidence, skewing research to what is easily studied, rather than what might be significant, yet difficult to quantify for scientific analysis.