“may be significant”

Given that the expression of TLRs is not limited to innate immune cells, but is extended in different T cell subsets, including conventional αβ T cells, regulatory T cells, and γδ T cells as well as natural killer T cells, we can speculate that TLRs may be significant for induction of effector and regulatory function of T cells [ 42 ].

15 Low adherence and high rates of discontinuation suggest that there may be significant unmet needs among patients with DED that is not being addressed by the currently available immunomodulatory agents.

Given the widespread immunity to MeV in the general population and the desirability of systemic administration as an approach for the treatment of metastatic cancer there may be significant advantages if this viral platform could be engineered to evade serum neutralization.

Time will tell whether the long-term impact on this population will be similar, and if it is, the consequences on this generation in terms of quality of life and economics may be significant.

11 There is increasing recognition that following hurricanes and other natural disasters, there may be significant mental health problems. 12 The most frequent psychological disorder following natural disasters is post-traumatic stress disorder (PTSD). 13 Children appear to be more prone to PTSD than adults following natural disasters. 12 The prevalence of PTSD appears to be related to the severity of the natur

Our hypothesis is that respiratory function and muscle strength may be significant predictors of mortality.

Conclusions The T allele and TT genotype of the GABRG2 C588T gene were more common among patients with IGE, whereas the G allele and the GG genotype of the GABRG2 3145G>A gene may be significant predictors of ASMs resistance among IGE patients.

However, based on the results of our previous studies, we hypothesize that there may be significant differences in the molecular-genetic regulation of the intensive stem elongation phase between mono- and dicotyledonous plants.

The energy of the recoil effect may be significant enough to cause the breakage of the bond between the daughter radionuclide and the ligand.

This may be significant to the weed's ability to evolve resistance under herbicide stress.

The impact of sea buckthorn addition on acrylamide formation in shortbread pastries may be significant due to its chemical properties, although research on this topic is scarce.

Studies among Chinese mothers (native and immigrant) suggest that in addition to psychosocial factors, cultural and familial factors may be significant in shaping Chinese mothers’ breastfeeding beliefs and practices [ 16 ].

This may be significant, as a number of neutralizing antibodies appear to bind sites in this domain.

This looming public health crisis will demand expansion of both health service and social service capabilities, as the necessary medical attention and reduced work capacity may be significant.

Complication rates are low but may be significant for their future implications.

Clinically, this may be significant, as these anatomical changes could contribute to increased refractive error, reduced accommodation amplitude, and potentially a heightened risk of cataract development later in life as indicated by others (Fieß, Fauer, et al., 2022 ), as well as to amblyopia. 4.1.

The regulation of transcriptional control by the telomeric components may be significant in aspects of cellular metabolism regulation.

Indeed, recent evidence has suggested that avatar personalization can improve overall engagement [ 49 ]; thus, there may be significant value in enabling this form of customization.

Furthermore, surgeon selection bias to include acromioplasty may be significant and associated with increased rates of revision surgery.

While there was no significant desaturation in our procedures, the low PaO 2 /FiO 2 gradient may be significant in patients with pre‐existing lung disease or hypoxaemia at baseline and may result in more desaturation when utilizing HRIVE.

Although we have yet to observe defects at these stages when these family members are disrupted, it may be significant that Patronin was observed in a juxta-centrosomal location, where it could mediate such a handoff.

The EU AI Act is one of the most significant examples of AI assurance regulation and one that may be significant in the development of future AI regulation.

Data synthesis and statistical analysis We anticipate that there may be significant heterogeneity in the prevalence of EAT features of CD.

The 2016 population was projected from 2015 population census data, 15 and the number of deliveries was derived using the World Development Indicators’ estimated crude birth rate per 1000 people for 2016 16 (the crude birth rate was used as there may be significant under-reporting of births through the District Health Information System, particularly for births that did not occur in health facilities).

Thus, even without the UTX mutations, anomalies affecting UTX expression levels such as haploinsufficiency and DNA methylation in the promoter region may be significant contributors to cancer formation 9 .