Barely Significant
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“may be significant”

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In the literature

Lastly, the validity of this formula may be compromised in specific patient populations where there may be significant derangements of biochemical profile, such as in-patient populations [ 39 ], hypogammaglobinemia [ 9 ], malignancy, hyperthyroidism, and jaundice [ 10 ], and application of our formula in these populations should be approached with caution.
However, given that they coexist with diverse bacterial species in the environment ( Oren, 2002 ; Kato and Watanabe, 2010 ; Orcutt et al., 2011b ) and can compete for similar resources, there may be significant, unexploited potential for antibiotics in this domain.
We used both poly:IC and LPS to highlight that regardless of signaling through TLR3-TRIF or TLR4-TRIF and MyD88, the effects of CYP450 lipid-PPARα axis acts further downstream of the signaling cascade which may be significant due to the difference in PAMPs detected in multi-pathogenic interactions with the host immunity in superinfection.