“may be significant”

Length of opioid treatment may be significant in patients with cancer.

In a study using brown planthopper as experimental model, it was shown that an ABC transporter coded by the gene NlMdr49-like is involved in IMD resistance [ 68 ], showing that ABC efflux pumps may be significant assets in protecting from IMD-induced cell damage through their efflux activity and thus reducing bioaccumulation.

In contrast, the SEARCH-CKD study extends our knowledge by examining multiple communities in more than one country using a pre-defined research protocol, and shows that even within a country, there may be significant differences in CKD prevalence.

Building on these data, it can be hypothesized that P-gp overexpression in MM cells may be significant for disease relapse.

In addition, increased diversity within the oral microbiota was observed, indicating that alterations in the oral microbial composition may be significant for individuals with migraines [ 15 ].

Therefore there may be significant changes in lipid kinetics in psoriatic individuals reflecting this defect in lipid homeostasis.

According to our findings, higher dietary diversity and moderate adherence to a “low fat plant-based” dietary pattern may be significant protective factors against AUB in university students.

The human skin chymotrypsin-like proteinase, which may be the human analogue to this proteinase, did not appear to degrade basement membrane collagen; the lamina densa remained intact even after 8-h incubations, and the presence of type IV collagen was documented by immunofluorescence. This suggests that there may be significant differences in the proteolytic suscep- tibility of isolated basement membrane proteins as compared with the same proteins in their native environments.

In general practice, an absolute z-score of >2 or <-2 may be significant.

Apart from physical, clinical effects and consequences of the donation procedure and psychological impact of donation may be significant both in positive and in negative sense.

Preterm births between 32 and 37 weeks of gestation have a relatively lower risk of mortality and morbidity than early preterm births, but the impact on healthcare worldwide may be significant due to their higher risks than full term births 22 , 30 .

This view was called into question, and alternatively, it was claimed and proven that state differences such as motivation, personal relationships, expectations, or demand characteristics amply researched by social-psychological and socio-cognitive hypnosis researchers (e.g., Spanos, 1991 ; Spanos and Coe, 1992 ; Kirsch, 2001 ; Lynn et al., 2019 ) play a much more important role, quite apart from the fact that situational and contextual conditions may be significant.

As a result, if small town is impacted by a coastal hazard there may be significant short- and long-term impacts on the town.

So, if the choice of focal distance results in significant defocusing of scene elements in one’s immediate vicinity (i.e., where stereopsis is most effective), and if defocusing disproportionately affects stereoacuity (Goodwin & Romano, 1985 ; Westheimer & McKee, 1980 ), the consequences for depth perception may be significant.

It is suggested that the ABCB1 3435C > T variant may be significant only in individuals with specific carcinogen exposure [ 6 ].

Some relevant physical effects are not included in the current model, but could be incorporated in future: for example, airway wall elasticity [ 10 ], which could enable modelling of transient airway collapse; mechanical interdependence of the acini, which has been incorporated in previous ventilation models [ 58 ] and extrathoracic deposition, which may be significant for large particles [ 5 ].

This suggests that there may be significant variability in the effectiveness of adrenal-sparing surgical techniques among different centres, with subsequent strong limitations regarding any conclusions made when comparing results from different series.

Because the statistical significance of individual patterns and sequences is assessed based on the overall number of their occurrences in the whole data set, they may be significant despite being rare; all that matters for them to be detected as being non-random is that they occur significantly more often in the original data than in the surrogate data, irrespective of other criteria like their particular time of occurrence or their complexity.

We choose to offer LITT to patients where surgical risks may be significant, while we continue to offer traditional open surgery to more superficial tumors (e.g., lobar tumor).

Indeed, zinc is an important mediator/messenger involved in several cellular activities and the shift of zinc from plasma to cells may be significant for both normal physiological processes including energy metabolism, blood coagulation, and zinc signalling, and a range of disease states, including neurodegenerative and cardiovascular diseases, metabolic syndrome, inflammation, endothelial stress, diabetes and thrombosis [ 91 ].

However, there may be significant limitations to this technique.

5 For other systems, there may be significant H 2 gas-phase contributions to reduction. 16 Conditions can be varied by the choice of reducing agents (i.e., metal hydride), reaction temperature and time, and the activity/concentration of H – .

However, there may be significant inter-species variation for this mechanism, and recent in vivo human imaging of P-glycoprotein did not detect significant changes at the piriform cortex ( 213 ).

However, this raises an important question: should new skills be learned directly on real patients? [ 20 ] There may be significant value in shifting the learning curve of the student into the simulation lab prior to patient encounters.

Considering that FISS is regarded as a chronic inflammation-associated tumor with histological features that are similar to wound healing, the expression of STAT3 may be significant and plays an important role in tumorigenesis.