“may be significant”

Biological heterogeneity: There may be significant differences in the biological characteristics of lung tissue among patients, including lung function, tissue response and individual sensitivity to radiation.

For instance, hearing loss may be significant in neurofibromatosis Type 2, while thyroid nodules are common in PTEN hamartoma tumor syndrome and DICER1 syndrome.

First, there may be significant species differences in MLR function, particularly given our bipedal gait and the dominance of our corticospinal tracts (Alam et al., 2011 ).

The identification of lung tissue is more tentative, but the proximity of cartilage, bone, and cells resembling embryonic respiratory epithelium, albeit non-ciliated, may be significant.

In fact, there may be significant differences in mental health symptoms between migrants who left for attractive reasons, such as education and job opportunities, and those who left for pushing reasons, such as war and persecution.

Such insights may be significant in the context of understanding the mechanism of ORFV125 regulation of apoptosis.

Although actigraphy has been validated in populations with schizophrenia 94 and bipolar disorder, 62 its specificity for sleep remains low, and the tendency to overestimate sleep time may be significant in individuals with sedentary behaviors.

However, with effective prophylactic medications in the immediate 1-year post-transplant, the risk of PJP nowadays may be significant several years after transplant when prophylaxis has been discontinued.

The rise in PTH at T2 may be significant.

One of the DosR regulon proteins, DATIN, encoded by the gene Rv0079, can stimulate macrophages and peripheral blood mononuclear cells to secrete important cytokines, which may be significant in granuloma formation and maintenance [ 47 ].

Another parameter that may have an important place in clinical practice and which may be significant in terms of real-life data is the other bleeding that does not meet the major bleeding criteria.

These populations with a wider genetic base may be significant to adapt future scenarios and used as source material for germplasm banks and/or nurseries (Poudel et al., 2014 ).

A more detailed analysis of the specific PF subsets allowed us to identify an increase in CD8 + CD56 dim CD16 Hi NK cells in EM patients, which may be significant given that the CD8 molecule typically enhances NK cell cytotoxicity [ 30 ].

52 , 59 Adapted Model 2: Extension to the Linear Response Approximation (LRA) Approach Equation 6 does not account for possible inherent ligand interaction energies with the protein in its unbound conformation, but depending on the system of interest, such preorganization energy may be significant. 60 In that case, the assumption of the linear response in the electrostatic interactions as taken in eq 6 can break down.

shows selected endothelial miRs that may be significant for treating PPCM by decreasing angiogenesis via the decreased proliferation of endothelial cells or accelerated senescence of endothelial progenitor cells, increasing endothelial permeability, decreasing TIMPs, and increasing MMP activity that may cause excess inflammation and fibrosis, and additionally by activating macrophages [ 98 , 99 , 100 , 101 , 102 ].

However, studies suggest that non-dietary routes of pyrethroid exposure may be significant in certain instances for children.( 47 ) An additional limitation is the crude assessment of pesticide use, no data on application dates or amounts were obtained during the study therefore our assessment was limited to reported pesticide use in the previous 6 months.

We also show that forelimb and hindlimb cells have inherent adhesive differences and that this may be significant in the generation of limb-type morphologies.

Cytokine gene polymorphisms may be significant for the diagnosis of endometriosis, as they can influence immune and inflammatory responses.

A differential miRNA expression pattern, involving 153 miRNAs, was detected in the present study, 52 upregulated and 101 downregulated, thus identifying those miRNAs that may be significant in breast cancer development.

This finding may be significant because it is cost-effective and easily assesses current inflammation and nutritional status, which can aid physicians in primary hospitals and outpatient clinics in evaluating DR occurrence especially when HALP score is lower than 42.9, and developing suitable treatment strategies through regulating hemoglobin, albumin, lymphocyte, and platelet.

In this study, the mean burden of AA in those with recurrence was <5%, suggesting that even in those who had recurrence, there may be significant burden reduction and consequent improvement in symptoms and QOL.

Economy-wide models help us trace the path of complex economic forces, and offer policy insights about indirect effects that may be significant and often counterintuitive.

There may be significant interactions between individual drivers of bifacial point shape, and these interactions can only be tested for by formulating models for this purpose.

Because of the cumulative interference caused by historical data in SOC estimation, there may be significant errors in the prediction results.

Additionally, differences in PD-L1 degradation between human and murine systems may be significant and cannot be ruled out.