“may be significant”

Although data from clinical trials suggest the risk is low, they are limited by the relatively low number of patients in the pivotal studies and the exclusion of participants with a higher burden of comorbidities; however, findings from postmarketing studies suggest the risk may be significant [ 7 , 14 ].

This may be significant in light of further results in the 2008 and 2018 studies.

However, higher power views of the staining of carcinomatous and hyperplastic regions with the three antibodies to CD133, Oct4 and ALDH7A1 revealed changes in PrCa versus BPH sections which may be significant.

efforts from many corners, the thrombolysis rates are still low, especially in the developing world.[ 2 , 3 ] Although the barriers for thrombolysis are many,[ 4 , 5 ] low acceptance among physicians may be an important factor.[ 6 ] Over-projected bleeding risk and subjective feel of futility[ 7 ] may be significant in this regard.[ 6 ] The clinical decision-making about IVTT varies among physicians.[ 7 , 8 ] The negative role of previous bad patient outcome in subsequent decision-making is well established.[ 9 ] In practice, most physicians remember a few patients who had no improvement (NI) or worsened following an IVTT.

Understanding the health consequences associated with the nutrition transition has been identified as a research priority in South Africa and other LMICs where implications in relation to health policy may be significant ( Popkin, 2002 , Reddy et al., 2012 ).

Furthermore, as in the EAE model, there may be significant differences in the response to treatment between a Th1 dominant HP pathology and a Th17 dominant pathology.

5 DISCUSSION If not corrected for, the deviation between the AEP in the radiotherapy treatment planning system and the stereographic projection in the OPTOS optomap image may be significant.

5 In addition, our results suggest that there may be significant potential benefit in healing rates and that, if this were confirmed in a full trial, the introduction of supervised exercise for VLU may well also save costs for the NHS.

It has recently been suggested that other comorbid conditions (such as painful bladder syndrome), myofascial contributors, and central sensitization of the nervous system may be significant in the pathophysiology of deep dyspareunia in endometriosis, in addition to endometriosis-specific factors (e.g., stage, location, and depth of invasion) [ 19 ].

2 It has been reported that in addition to critical illness, there may be significant effects on appetite, conscious state, and direct gastrointestinal effects resulting in nausea, vomiting, diarrhoea, and feeding intolerance.

This finding may be significant considering the current limitations of sepsis diagnosis, which often relies on clinical criteria and non-specific markers.

CXCL13 expression has also been reported to be upregulated by interleukin 6 (IL-6) through an unknown mechanism, which may be significant in BM-PCa, as IL-6 levels are observed to be higher in PCa patients with bone metastases ( 128 , 132 , 133 ).

The benefits of such a device may be significant and should be contemplated, particularly for selected cases where risk of microbial exposure is deemed greatest.

To the best of our knowledge, there has been no study of striatal synaptosome preparations comparing PD to controls and there may be significant technical limitations to this approach with postmortem tissue.

These findings may be significant for NSCLC treatment as RNF123 was shown to suppress NSCLC proliferation and cellular activity in A549 and H1975 NSCLC cell lines, potentially emerging as a new target for treatment.

However, analysis of the dynamics of acquired resistance suggests that there may be significant differences between the underlying mechanisms in C. albicans and in the C. parapsilosis species complex [79] .In C. parapsilosis exposure to fluconazole, voriconazole or posaconazole results in a more rapid acquisition of resistance than in C. albicans , and the resistance levels are stable over at least 30 days following removal of the drugs [79] .

This may be significant because enhanced or premature chondrocyte cell death may trigger subsequent events that accelerate degradation of cartilage.( 17 ) It was shown in articular chondrocytes that TNF-α-induced apoptosis was associated with increased expression of genes related to matrix degradation such as MMP and macr

This may be significant for the reduction of tissue damage induced by excessive recruitment of leukocytes, particularly neutrophils, during an immune response.

Hyperglycemia, along with older age of the patient, clinical indicators of systemic inflammatory response, and multiorgan failure, may be significant in predicting disease progression and mortality [ 52 ], which was also observed in our study.

This may counteract the reduction in effective recombination rates caused by inbreeding, to such a degree that the strength of BGC may be significant.

Thus, information such as Sync.com users, passwords, session IDs, network traffic, prefetch file listings, link files, and browser history were shown to be definite clues to identify the content of the files that may be significant in solving a particular case.

Second, there may be significant variation within a county in access to care or other socio-ecological variables that influence HIV clinical outcomes.

The exercise-induced rise in β-endorphin levels may be significant as it has been found that higher levels were associated with fewer smoking relapses after cessation [ 27 ].

However, recent studies have found that there may be significant differences in the clinical outcomes of patients at the same disease stage.

Among physician practices like RHCs, size and ownership may be significant contributors to ACO participation.