On the other hand, it should be considered that in chronic painful conditions, especially neuropathic injuries such as in shingles, post-herpetic and trigeminal neuralgia, and in more subchronic hypersensitivies such as following burn injury [ 130 , 131 ] or even sunburn [ 28 , 132 ], the phenotypic sensory change is such that mild tactile stimulation and stroking can now be perceived as highly painful in the affected dermatome, and accordingly there may be significant anti-allodynic benefit to P2X3 antagonism, with the potential even for topical application.
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In the literature
The presence of elevated proportions of free oestradiol in the serum of women with breast cancer may be significant in regard to understanding the aetiology of breast neoplasia.
Last, we aimed to extract notes that may be significant for organizing and implementing interdisciplinary follow-up care for suicide attempters in a pediatric setting. 2.
Hfq limitation may be significant under certain conditions ( 56 , 57 ), leading to a reduction in target transcript-RyhB coupling and thus target degradation, thereby limiting the range of possible fluctuations for given production rates of RyhB and its targets transcripts.
In summary, due to the different measurement tools, there may be significant differences in the ability of the two types of JE scales to predict nurses’ turnover intentions.
At 19 participants, it was possibly underpowered, and we believe the congruency effect in the blue condition may be significant with greater participant numbers.
62 Therapeutically, the activation of Akt by PTEN inhibition may be significant in maintaining neuroprotective properties.
There may be significant heterogeneity in the health status of older individuals at the same chronologic age, and this study demonstrated that age alone is insufficient to inform on medical financial hardship.
This result may be significant because CDKN2A is commonly mutated in a number of difficult-to-treat cancers, such as glioblastomas and pancreatic ductal adenocarcinomas.
However, we note that ND is not accounted for in current gas phase experiments and this process may be significant.
However, there may be significant risks associated with clinicians missing an underlying autism presentation, particularly if this leads to unnecessary medicalised treatment of a misdiagnosed alternate mental illness such as schizophrenia or bipolar disorder (Au-Yeung et al., 2019 ; Luciano et al., 2014 ; Van Schalkwyk et al., 2015 ).
On the other hand, as shown in Figures 2(b) and 2(c) , the friction and passive forces may be significant and the pavement edge can move laterally and vertically [ 7 ].
This may be significant, as repeated introduction and removal of an instrument could spread tumor cells through the surrounding tissue and contribute to the high local recurrence rates observed in lesions treated with curettage.
The splitting tensile strength evaluates the resistance to forces applied perpendicular to the axis of the material, which may be significant for understanding how polycarbonate interacts within the concrete matrix.
It can be seen that the Cu NW TEs have a high transmittance which may be significant for improving the light extraction from the LED active layers.
In terms of horizontal coordination, the results indicate that public agencies serving major metropolitan areas—such as the great Houston, Austin, San Antonio, and Dallas–Fort Worth regions, all exhibit relatively higher levels of content and relational coordination with the rest of the public organizations in the ecosystem, implying that the scope of service, as well as heightened disease risk in these areas, may be significant external forces driving such coordination.
The exclusion of elevation from the list of selected variables may be significant in this low performance of the physiographic variables with respect to species richness.
Insulin care delivery: Skills and systems The insulin-related skills and attitudes of primary care HCPs may be significant in determining the use of insulin and the outcomes achieved.
Therefore, any differences observed in the pollen biology of allergenic plants may be significant for allergy sufferers.
if entry screening is implemented, States should take into account the following considerations: it offers an opportunity for individual sensitization, but the resource demands may be significant, even if screening is targeted; and management systems must be in place to care for travelers and suspected cases in compliance with International Health Regulations (IHR) requirements ” [ 5 ].
Although the amount of physical activity is less than the recommended 10 min bout [ 20 ], the volume may be significant when accumulated over the long run as found in one prospective study where by men had a 29% decrease in stroke risk associated with stair use [ 10 ].
Therefore, LBC may benefit less from the emotional support, good public norms and resources associated with neighborhood cohesion, and the role of neighborhood cohesion in suppressing the family income gradient in depression may be significant among only the NLBC.
These results suggest that ICS and ICS+LABA use may be significant risk factors for fractures and that fracture risk can vary based on BMD status.
Thus, there may be significant and unintended effects on non-target organisms.
In general, cattle that have higher viral loads of IDV and ICV also have greater numbers of coinfecting viruses than controls, suggesting that ICV and IDV may be significant contributors to BRDC [ 7 ].