Barely Significant
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“may be significant”

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In the literature

The presence of a large number of clostridial endospores (more than 5 per oil field) on Diff-Quik–stained smears may be significant, but a positive fecal enterotoxin assay (enzyme-linked immunosorbent assay [ELISA] or reverse passive latex agglutination) is likely more significant.
Small Intestine
Canine and Feline Gastroenterology · 2012 · PMC7152060
That the obese rely greatly for cooling on the evaporation of sweat is shown by the difficulty they experience in warm humid surroundings. It has not been possible to find evidence of over-clothing amongst the obese, but it may be significant that most of them are engaged in indoor occupations, under equitable conditions of temperature.
The Problem of Obesity.
Edinb Med J · 1931 · PMC5322054