“may be significant”

New techniques such as dose escalations may be significant challenge which may limit the application of current margins.

However, the sample sizes extracted from different regions differed considerably, and the deviation between the sampling results and the population may be significant.

Both FIT and Cologuard indicate that there may be significant costs associated with saving colorectal cancer screening methods, with FIT as the primary non-invasive method [ 31 ].

The shortened treatment time may reduce the impact of intrafraction motion, which may be significant in intraabdominal radiotherapy.

Miscibility-driven phase transitions in compressed matter are very important for planetary modeling for two reasons: (i) they may be significant enough to define layer boundaries prohibiting full convective mixing within the planet and, thus, strongly influence the mass distribution inside planets 6 and (ii) heavier components created by demixing will liberate gravitational energy by precipitation and, thus, may strongly modify the energy balance of the planets.

In health system lacking significant stakeholders such as school nurses and school physicians, the contribution of OPh may be significant.

Thus, it has been suggested that this autophagy-mediated phenomenon may be significant in contributing to general CD4+ T cell losses during the course of HIV infections ( Espert et al., 2006 , Espert et al., 2007 , Levine and Sodora, 2006 ).

In the case of alcohol-based HCPs, a previous study on benzyl alcohol suggests that its contribution to SOA formation may be significant, potentially occurring through adsorption or absorption of oxidation products.

Considering the absolute number of participants (approximately 18,000 in both congresses) the percentage of Tweets received (about 2%) may seem very low, but considering that it was a first "urological" experience, I think it may be significant.

This is an interesting finding and may suggest that in addition to conventional features such as grade, nodal status and ER status, cytokeratin expression may be significant in the role of response to PET.

Taken together, our results suggest that care is needed in interpreting MIC tests and other laboratory growth assays for β -lactam antibiotics, since there may be significant degradation of the antibiotic during the assay. http://dx.doi.org/10.13039/501100000266 Engineering and Physical Sciences Research Council http://orcid.org/0000-0002-0101-4194 Brouwers Rebecca http://dx.doi.org/10.13039/501100000781 European Research Council 682237 EVOSTRUC http://orcid.org/0000-0003-4110-2962 Allen Rosalind J.

It may be significant that one of the Ca 2+ sites detected by crystallography involves the key site A ligand, Asp248 (corresponding to Asp249 in human albumin) and indeed, Ca 2+ ions were found to interfere with the 113 Cd signals for both sites A and B of human albumin [46] .

Heterogeneity analysis Considering the stress that rural youth face and the different ways in which they cope with stress, there may be significant differences in how stressors impact public participation behaviors.

This may be significant since Ephrin-Eph signaling is important in maintaining angiogenesis and proliferation of immature mesenchymal cells.

74–78 Thus, at low formate coverages, there may be significant attractive interactions among the adsorbed formate species on Cu(110) which contribute to the difference between experiment and theory observed here.

These findings indicate that entry PT and exit PT occur at distinct rotational angles of the c -ring, implying that the angular mismatch may be significant for F o ’s efficient rotation.

However, there may be significant fluctuation of symptoms, onset of relapses, and accrual of disability in between clinic visits that are not well measured by this clinical visit schedule.

That is, the breadth of the P-Lattice representation in the brain may be significant.

Furthermore, community-based obstetric violence norms may be significant drivers of violent obstetric practices and experiences at health facilities in Central Tanzania.

For strongly localized orbitals, self-interaction may be significant and spuriously destabilize electron energies. 26 The situation can be improved, if one uses “hybrid” DFT, i.e., functionals that contain exact exchange based expressions employed using a nonlocal Fock operator. 26 We emphasize that while such functionals do not fall within the KS scheme, they are still very much within the DFT framework 3 , 26 , 47 through the generalized Kohn–Sham (GKS) scheme. 48 In the KS scheme, many-body effects are incorporated entirely in a multiplicative potential (which is the sum of the Hartree and exchange-correlation potentials).

In addition, interactions of nonnucleoside drug combinations on lipid metabolism may be significant in a setting where stavudine was most often given with nevirapine.

A corollary is that there may be significant O 2 ·− formation within mitochondria that goes undetected, which is supported by the finding that H 2 O 2 efflux from mitochondria increases with peroxidase inhibition [ 54 , 56 ].

The colocalization of proteins involved in Wnt-mediated β-catenin stabilization in close proximity to nuclear pores may be significant, as β-catenin is able to traverse independently of the importin/karyopherin nuclear transport system ( Fagotto et al. 1998 ).

This may be significant as there have been several reports of lower selenium levels in African American populations, including those in Chicago from whose tissues were used to generate the TMA described here [ 25 , 38 – 40 ].

Several significant correlations between miRNAs and mRNAs previously linked to schizophrenia and brain function suggest potential miRNA-mRNA interactions that may be significant for disease pathophysiology. status released display-pdf yes is-olf no is-manuscript no is-preprint no is-journal-matter no is-scanned no is-retracted no Issue date 2018 Apr.