“may be significant”

The tumor suppression potential of GRWD1 in KRIC and its correlation with MSI and the CD274 gene may be significant for the therapy of KRIC.

Despite being a rare complication, delayed or undetected vascular injuries following any procedure may be significant.

Thus, it may be significant that despite extreme sequence diver- gence in cytoplasmic domains, a consensus protein kinase A modification site (Krebs and Beavo, 1979) between positions 220 and 240 exists in both the human liver and frog em- bryonicjunction proteins (at residue 227 in Xenopus).In con- trast, the two consensus tyrosine phosphorylation sites (Pat- schinsky et al., 1982) in the carboxy-terminal domain of the human protein (Kumar and Gilula, 1986) are absent in the frog sequence.

Thus, it may be significant in larger systems which require complex regulation.

Hence THP12 (1C3Y) might represent a more reasonable template for DhelOBP21 than other proteins from Hymenoptera, Lepidoptera, or Dipterans, such as AmelOBP14, BmorGOBP2, or AgamOBP1, respectively (3) The sequence similarity between 1C3Y and DhelOBP21 is 42% (E-value: 2e-21), which is the significantly higher than the others (27% or lower) and this difference may be significant.

Disability is reported in more than 90% of ET patients who seek medical care and may be significant enough to warrant invasive surgery such as deep brain stimulation (DBS) or thalamotomy ( 21 ).

Several observations may be significant.

However, it is important to note that even if environmental factors account for a small contribution to the variance explained in health-related outcomes, their effects on health at the population level may be significant and consistent over time [ 61 ].

This means that there may be significant drought response differences even in the small-scale terrain, and the amount of difference in resilience-related indicators (recovery, resistance, or resilience) cannot be estimated only by the elevation difference.

After these tests, the changes in bacterial densities between the beginning of the study and after 6 weeks were separately calculated for each participant by taking the logarithm according to base 2, in case the high variation in the microbiota composition of the participants, the small number of participants, and the presence of a high number of bacteria at the genus level may overshadow the determination of species that may be significant with BH correction.

Given other emerging evidence of hypercytokinemia in hospitalized COVID-19 patients ( Yang et al., 2020 ), the burden of long-term post-SARS-CoV-2 delirium may be significant, particularly for elderly patients who are more susceptible to post-infectious neurocognitive complications. 2.2.

Therefore, the choice of detection method in early-phase trials may be significant, as it can influence the characterization of the enriched patient population and the subsequent interpretation of efficacy signals ( 63 ).

Our data add to the weight of evidence suggesting that the ATX-LPA signaling nexus may be significant in regulating vascular vessel remodeling in adult animals.

The risks of overdiagnosis of CKD may be significant in patients with cirrhosis since many of them belong to the old age group.

CCL5–CCR5 association is a key regulator of endothelial progenitor cells’ homing during wound healing, suggesting that CCL5 may be significant as a general B cell coactivator [ 14 ].

Other transition metals that may be significant for human health and physiology are iron, manganese, selenium, cobalt, and chromium [ 1 ].

R81 methylation may be significant in the context of craniofacial development and cranial suture closure because compromised Smad6 function has been associated with the occurrence of craniosynostosis ( 35 , 36 , 37 ), a congenital condition characterized by premature fusion of bones that form the cranial vault.

Due to the non-stationarity of MI-EEG signals, there may be significant differences in EEG features between the training and testing datasets.

22 It is well known that GCs inhibit the mRNA transcription of proinflammatory genes, which may be significant to reducing neutrophilic inflammation due to evidence that lung-transmigrated neutrophils exhibit a rapid burst of inflammatory transcription on arrival in the airspace. 137 However, GCs have generally failed to show efficacy in ALI/ARDS in human clinical studies. 138 Indeed, the influence of GCs in infection-induced acute injury appears pathogen-dependent.

The expected improvement in psoriasis associated with weight loss may be significant but not too clinically relevant: weight loss following lifestyle interventions (diet or physical activity) improves psoriasis compared with control [mean change in Psoriasis Area and Severity Index − 2.59, 95% confidence interval (CI) − 4.9 to − 1.09; P < 0.001] [ 23 ].

Secondly, the data include a range of self-reported behavioural characteristics, where noise levels may be significant.

18 reported only correlations and there may be significant bias when applying a model developed from a Spanish population to a Japanese population, which could have clinical consequences.

A positive gene diagnosis may be significant for the early detection, prognosis, and risk assessment of close relatives, and genetic testing may be beneficial for patients with high FIP and positive gene probability 101 .

Although there may be significant variation due to species diversity, a recent preprint for a bat single-cell atlas of Rhinolophus sinicus ( Ren et al., 2020 ) suggests comparable IRF1/3/7 expression, with RNA expression observed across both lymphoid and non-lymphoid tissue, matching our own observations.

These results suggest that the increase in ROS induced by cryopreservation, along with the corresponding decrease in antioxidant gene expression, may be significant factors influencing sperm quality and function.