“may be significant”

The financial impacts of this may be significant as some individuals with young onset dementia are at the height of their career and have financial obligations such as mortgages or children’s educational expenses ( Harris, 2004 ; Roach et al., 2008 ).

Immunostaining of breast tumor indicated that downregulation of p27 correlated with HER2 gene overexpression in primary breast carcinomas, which may be significant in selecting patients for HER2-positive/neu antibody therapy in the future [ 82 ].

Although these targets may not be directly generalizable to untreated populations, they may be significant when implementing strategies for prediabetes screening and T2DM prevention.

In subsequent focus groups, healthcare professionals were positive about parental engagement, although they considered that there may be significant challenges.

Another consideration is related to cost: although digital workflows ultimately reduce manufacturing variability and enable rapid component reproduction, the initial investment in technology, training, and software licensing may be significant, if compared with traditional appliances.

Each tumor type has distinct biological characteristics; therefore, there may be significant differences in the effects of exercise interventions ( 227 ).

21 , 25 A context in which cotransport may be significant relates to the bioavailability of organic contaminants in soils and sediments and consequently to pollutant biodegradation and soil remediation attainment.

Although fly involvement in virus movement between commercial poultry facilities is probably minor relative to other means of virus movement (e.g., on personnel, shared equipment, or manure hauling vehicles), fly involvement in virus movement among poultry houses at a single commercial facility or among backyard poultry may be significant given the short distances flies would need to move between infected and uninfected poultry.

Alternatively, there may be significant heterogeneity among individuals that is currently not captured by the coarse diagnostic categories in current use.

Our measurements demonstrate that for light to intermediate weight ions (C, N, O), the track structure impact on OER is negligible, while it may be significant for heavier particles, such as Si (see triangles in Fig. 3 ).

There may be significant financial savings associated with reducing the number of unnecessary G&S and post‐operative blood tests, and a formal health economic review may be of value in the future. 4.5 Conclusions In summary, our study outlines a means of selecting patients for G&S and post‐operative Hb measurement based on the risk of developing severe post‐operative anaemia.

However, liquid chromatography‐mass spectrometry (LC‐MS) analysis showed that there may be significant differences in lactylation sites K3, K143, K162, K263, K450, and K523 in Ezrin (Figure 7C ).

The latter results indicate that while the ecological advantage of genomovars DW07 and CZ05 at high-salt conditions may be significant, it is apparently not strong enough to purge diversity within the species (i.e., completely outcompete remaining genomovars), and genomovars that may be less-adapted to high-salt concentrations (e.g., CZ34 and CM11) appear to survive such (unfavorable) conditions, presumably as (viable) members of the rare biosphere.

Our case study of government-targeted blaming in relation to Covid-19 and Brexit suggests that there may be significant variation within strategies that are used to blame the government over one particular policy failure or controversy.

Slight amounts of water may accumulate on the surface of hydrophilic edible films using the cup method, and the resistance of the stagnant air layer between the bottom side of the film and the surface of the saturated salt may be significant, and, if neglected, may underestimate the water vapor transmission rate ( WVTR ) [ 18 , 46 ].

While it's commonly believed that the detrimental redox changes observed in PD stem from mitochondria, emerging evidence suggests that oxygen-related oxidant species production is influenced by a functional interplay between mitochondria and NOX2 [ 21 ], which may be significant in neurodegenerative processes like PD [ 22 ].

While such reactions are relatively uncommon, they may be significant for specific chemotypes that are chemically labile under acidic or oxidative conditions.

However, we should take into account that the levels of PS-MNPs used in these studies may be far beyond the levels that are present in blood, and that there may be significant cross species differences.

In this regard, the importance of the crusts and erosions in virus transmission, be it vector-borne or in-contact, may be significant.

Additional examples where the trade‐off of afterslip and viscoelasticity in models may be significant include following the M w 7.8 2015 Gorkha earthquake (e.g., B.

In addition, in large sample sizes, a Pearson’s r close to zero may be significant, despite the fact that the linear association between two variables is weak and a significant correlation does not necessarily mean that a strong linear association exists [ 52 ].

Currently, the functional consequences of the sustained upregulation of unphosphorylated STAT isoforms are unclear but it may be significant that evidence in other cell types implies that STAT molecules can drive MHC class I expression despite persisting in a de-phosphorylated form ( Poat et al. 2010 , Srivastava et al. 2015 ).

Several new reports in the surgical literature suggest there may be significant differences in treatment and outcome based on the patient's gender.

Although the operative risk may be significant, it has been suggested that cystectomy can significantly improve these patients’ health-related quality of life postoperatively.

Although these vital sign changes produce no clinical change in most, they may be significant in individuals with tenuous cardiopulmonary status.