Barely Significant
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“may be significant”

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In the literature

The differences in functional enrichment between ALL prioritized and housekeeping prioritized genes suggest that the genes prioritized from the ALL specific training genes may be significant in leukemogenesis as their enrichment analysis is populated by pathways that are known to be deregulated in ALL. 3.3 Protein–Protein Interaction (PPI) network After identification of prioritized genes, we investigated protein associations using the STRING database.
It is suggested that erroneous conclusions might be drawn because of the absence of in-depth consideration of unobserved data heterogeneity, arguing that “There may be significant heterogeneity in the data across unobserved groups, and it can bias parameter estimates, lead to Type I and Type II errors, and result in invalid conclusions” ( Becker et al., 2013 ).
This includes the distinctive modulation of terminally differentiated effector CD8 + T cells, which could may be significant in the treatment of immunologically “cold” tumors that exhibit poor immunotherapy responses. 28 In a murine HCC model, the combination therapy of anti-CTLA-4 and antiPD-1 monoclonal antibodies increased the infiltration of CD8 + and CD4 + T cells into tumors as compared to monotherapy, while reducing the infiltration of Tregs.