“may be significant”

to expand the loading space in the exosomes may be significant to improving the encapsulation rate of drugs into exosomes, which will also avoid the passive influence of exosomal contents on the treatment effect.

This suggests that there may be significant differences between the cell line and the primary cells and highlights how prenylomic profiling can be used to hone in on those differences.

Thermal decorrelation is caused by the noise added by the receiver and may be significant especially in areas where the Signal-to-Noise Ratio (SNR) is low, such as the ground.

HDL-c is a lipoprotein of cardiovascular protection and, it can be suggested that low levels of HDL-c may be significant factor of cardiovascular risk in urban patients on ART.

The role of BH 4 may be significant in lipogenesis, but no direct biochemical evidence has confirmed the importance of BH 4 in lipogenesis.

Namely, one needs to be careful when drawing conclusions based on the blocking climatology alone, since there may be significant differences in the meteorological character of individual blocks.

if the radicals are constrained), or once other anisotropic interactions such as the magnetic dipole-dipole interaction are present, which may be significant when the radicals are located close to each other.

It may be significant that the number of CGG-specific plasma cells fell more than the number of NP-specific cells and that the proportion of BrdU-labeled CGG-specific plasma cells remained higher.

Increased levels and phosphorylations of keratins in LSPC may be significant: LSPC is believed to be an important factor contributing to the pathogenesis of CAC, but levels of keratins in quiescent LSPC points towards a protective mechanism in this situation.

Consequently, B cells may be significant in the prognosis of HNSCC patients and may work as a predictive biomarker for immunotherapy [ 51 ].

Although there is little consensus on indications to preserve hypogastric blood flow during aneurysm repair, it is well understood that complications from bilateral hypogastric occlusion may be significant.

It may be significant that the outer region, previouslyoceupied by osmiophilic material (Fig.

This discrepancy may exist, in part, due to the proportion of patients with advanced liver fibrosis in clinical studies, where side effects or drug-induced liver injury may be significant issues.

In summary, together with induction of anti-cancer activities, there may be significant benefits in blocking the activation of adaptive pathways in order to improve the outcomes of a specific treatment in cancer patients undergoing therapy.

The mortality rate is relatively low, but morbidity may be significant and permanent neurological deficits can occur.

This difference indicates that there may be significant differences between IMQ-induced psoriasis mouse model and clinic psoriasis patients.

In patients who were diagnosed early and treated appropriately with cessation of ASMs, there may be significant improvement in cognition, particularly in executive and language functions and adherence with other treatments. 35 , 36 , 37 Because 60%–90% of patients with epilepsy report adverse effects of ASMs, which have a significant impact on quality of life, patients are often eager to come off

These drugs may have a narrow therapeutic index (antiarrhythmics, anticonvulsants, immunosuppressants, theophylline) or the decrease in their plasma levels may be significant/undesirable (oral contraceptives, benzodiazepines, opioids).[ 70 ] Caution is advised in the form of clinical/laboratory monitoring following the initiation/withdrawal of tocilizumab and the dosage of the CYP450 substrates adjusted accordingly.

Whereas, the PI accompanying the meta-analytic models of the association between MAP and T2DM had a narrower range suggesting a possibility that there may be significant/strong association between MAP and T2DM in the future.

Because the existing serum biomarkers lacked high sensitivity and specificity for the surveillance of metastatic or recurrent disease in colon adenocarcinoma, it may be significant to determine the cut‐off value of CD276 and use as a biomarker for early alarming tumor recurrence after surgery [ 24 , 25 , 26 ].

Consequently, there may be significant geographic, economic, or socio-cultural barriers and facilitators to providing and receiving social support.

Regarding working conditions, the acknowledgment of workplace bullying as a recognized OSH risk [rather than an employment issue, see Millis ( 113 )] may be significant for women migrant workers, due to the impact of this reported in international studies ( 20 , 83 ).

However, in terms of comparison of the BBS scores at the end of treatment, although the mean BBS score in the experimental group was larger than that in the control group, there was no significant difference between the two groups. Such a condition may be attributed to the relatively small sample size, and in a larger-scale study, the difference between the two groups may be significant.

From a resource utilization perspective, although the upfront costs of ADC implementation may be significant, the long-term gains in workflow efficiency, staff time savings, and patient throughput can justify the investment, particularly when paired with ongoing quality improvement initiatives [ 32 ].

Finally, the private insurance market may be significant in the following manner.