Barely Significant
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“may be significant”

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In the literature

However, given that ibrutinib may be administered continuously for years, the toxicity associated with prolonged antiviral prophylaxis and drug-resistance may be significant. 8 Previous studies on much smaller series of patients reported a variable incidence of reactivation ranging from 0% to 13%. 4 , 6 , 7 In our cohort, with a median duration of ibrutinib treatment of 12 months, only two of the 108 patients developed a HBV reactivation with a cumulative incidence of 1.9%.
The recombination of c -C 4 H 5 with I, on the other hand, may be significant; since c -C 4 H 5 is expected to react slowly toward C 2 H 2 , it persists longer in the reactor and can react with I over long time scales, potentially influencing the formation of C 4 H 5 I.
Emphasise the importance of the main joints due to their connection with the level of autonomy and those activities that may be significant for the patient; (iv) Promote a healthy personal and social environment where the person is valued in all their social spheres, taking into account the environment and context in which the person's occupational performance takes place; and (v) To analyse the roles that the person has played and that are important to the client can help plan a more client‐centred treatment and achieve greater adherence to treatment. 4.1 Limitations of the study This study has several limitations that should be considered for its accurate interpretation.