Barely Significant
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“may be significant”

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In the literature

The C and N contents of soil microbial biomass are mostly lower in conventional practices compared to organic practices, suggesting that there may be significant disturbances in the microbial biomass of conventional practice and that the persistent intake of organic waste with rich C/N ratio resulted in an increase of microbial biomass [ 217 , 223 ].
Effects of Abiotic Stress on Soil Microbiome.
Int J Mol Sci · 2021 · PMC8396473
This may be significant in concomitant treatment with selective serotonin re-uptake inhibitors and other drugs such as tricyclic antidepressants, serotonin 5-HT 1 receptor agonists (triptans), direct or indirect sympathomimetics (including adrenergic bronchodilators, pseudoephedrine or phenylpropanolamine), vasopressor agents (such as epinephrine or norepinephrine), dopaminergic agents (such as dopamine or dobutamine) as well as pethidine or buspirone.