Barely Significant
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“may be significant”

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This study revealed that the inflammatory response may be significant from the early stages of the infection, probably due to the role of Wolbachia spp. and the vascular damage caused by the adult worms in the pulmonary arteries, taking into consideration that the lesions begin immediately upon arrival of the parasites and worsen with the chronicity of the disease [ 4 , 104 ].
While the modest relative cost-savings of ISBAS over TSBAS ($2174) do not justify the unlikely but catastrophic potential of a bilateral blinding complication, the trend toward saving 33 min of general anesthetic exposure may be significant as our understanding of the impact of early general anesthesia exposure on children is elucidated.
EGF is also important for thyroid metabolism (Mincione, et al., 2011 ), which may be significant, given the early thyroid cancer identified in the proband (Figure 1 ). 3.5 Additional maternally inherited variants The two affected siblings and the unaffected brother inherited a maternal TRAP1 variant, Thr535Ser, with a PM1 classification.
Based on the protein contacts at the dimer interfaces (see Table 1 ) and the spatial location on the protein surface of the residues involved in the contacts, we propose that HEWL possesses three regions which may be significant for protein–protein interactions (see Figure 6 and Supporting Information movie binding_sites.avi).