Barely Significant
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“may be significant”

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In the literature

The finding that neutralization of these chemokines is associated with maintenance of antiviral effects but diminished tissue damage may be significant for the development of immunotherapeutic approaches for the treatment of chronic HBV infection.
Despite the use of a uniform definition for ARDS, there may be significant regional variations in incidence and outcome due to a number of factors, including seasonal variation, aetiology, management, study methodologies, environmental pollution levels, cigarette smoking, alcohol habits, clinical comorbidities, race, differences in the overall structure of health care, burden of diseases requiring ICU admission, ICU staffing, variations in the number of ICU beds, hospital policy on ICU bed utilisation, and availability of intensive care services [26] , [27] , [28] .
5d ), and suggest that the formation of the IP3R3-GRP75-VDAC1 complex and the changes in the structure and function of MAMs may be significant cellular responses in microglia triggered by eATP-P2X7Rs signaling, potentially contributing to CSDS-induced microglia responses and the development of depression-like phenotypes.
1 Although the incidence of IBD in patients treated with ISO is low, the consequences for an individual developing IBD may be significant. 21 Doctors can avoid providing ISO to IBD susceptible patients as much as possible by inquiring about family or personal medical history, in order to avoid serious consequences.
17 , 19 The distinction between aortic and peripheral artery pressures may be significant due to the phenomenon of SP amplification 18 , 32 : due to the difference in elasticity between aortic and brachial arteries, the SP measured at the brachial artery is amplified from reflected waves and can thus introduce errors when applying centrally derived formulas to peripheral measurements. 19 Routine measurements of blood pressure are not conducted centrally, therefore it is important to validate and determine the optimal MAP formula at a peripheral artery for comparable results.